Reviewed, UniProtKB/Swiss-Prot A1UQY9 (ARLY_BARBK)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BARBAKC583_0054

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Argininosuccinate lyase HAMAP MF_00006		PRO_1000000452

Sequences

	Sequence		Length	Mass (Da)
	A1UQY9-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 1C66998A101CB525	FASTA	466	51,699
	10 20 30 40 50 60 MTGDKLSNQM WGGRFAAGPA AIMEEINASI DFDQKLYRQD IEGSLSHAAM LAQTKIISHS 70 80 90 100 110 120 DYEKIVHGLQ LIRQEIETGS FTFSRKLEDI HMNIEARLSE LIGPVAGRLH TARSRNDQVA 130 140 150 160 170 180 VDFRLWVREA AQKIAQALKD LMEQLLMRAE QHADTLMPGF THLQTAQPVT FGHYMMAYVE 190 200 210 220 230 240 MFGRDLSRMR DAIERMNESP LGAAALAGTG FPIDRFMTAQ ALGFREPTRN SIDSVSDRDF 250 260 270 280 290 300 ALEFLSAGAL CAMHLSRLAE EIILWSSAQF HFIRLSDAFS TGSSIMPQKR NPDAAELVRA 310 320 330 340 350 360 KAGRLNAALM GLLTVMKGLP LAYSKDMQED KEYVFDGVLN LELSLAAMMG IISDLEVNKE 370 380 390 400 410 420 AMKQAAGSGY AIATDLADWC VRELGLPFRE AHHITGRAVA LAEQKKCSLD ELSLDEFQTL 430 440 450 460 HPDINAAVFD VLTIEKSVES RNSFGGTAPS EVLRQVAYWK QHLVTA

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM45432.1.
RefSeq	YP_988392.1.
3D structure databases
SMR	A1UQY9. Positions 19-464.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UQY9.
Genome annotation databases
GeneID	4684917.
GenomeReviews	Gene locus BARBAKC583_0054 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0054.
NMPDR	fig|360095.3.peg.1027.
TIGR	BARBAKC583_0054.
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	ATDTRLY.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BARBK

Accession

Primary (citable) accession number: A1UQY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)