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A1UQV8

- MDH_BARBK

UniProt

A1UQV8 - MDH_BARBK

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADUniRule annotation
Binding sitei83 – 831SubstrateUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei96 – 961NADUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei176 – 1761Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADUniRule annotation
Nucleotide bindingi119 – 1213NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-22-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:BARBAKC583_0022
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Malate dehydrogenasePRO_1000026465Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0022.

Structurei

3D structure databases

ProteinModelPortaliA1UQV8.
SMRiA1UQV8. Positions 1-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYAPSAFV.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UQV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRKKIALIG SGMIGGTLAH MIGLKELGDI VLFDVAEGLP QGKALDIAES
60 70 80 90 100
SPVDGFDINL TGANAYEAIE GADVIIVTAG VARKPGMSRD DLLGINLKVM
110 120 130 140 150
EQVGAGIKKY APSAFVICIT NPLDAMVWAL QKFSGLPAQK VVGMAGVLDS
160 170 180 190 200
ARFRYFLSQE FNISIKDITA FVLGGHGDSM VPLVRYSTVS GIPLPDLVKM
210 220 230 240 250
GWTTHEKIDQ IVQRTRDGGA EIVSLLKTGS AFYAPASSAV AMAEAYLKDT
260 270 280 290 300
RRVLPVAARL SGEYGIKDMY VGVPVVIGAG GVERVIEIDL NDNEKSAFEK
310 320
SVNAVKELCK TCSALAPNLK E
Length:321
Mass (Da):34,103
Last modified:February 6, 2007 - v1
Checksum:iD1A3476775EC282C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM44647.1.
RefSeqiYP_988361.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM44647; ABM44647; BARBAKC583_0022.
GeneIDi4684498.
KEGGibbk:BARBAKC583_0022.
PATRICi20536319. VBIBarBac6912_0022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM44647.1 .
RefSeqi YP_988361.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UQV8.
SMRi A1UQV8. Positions 1-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_0022.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM44647 ; ABM44647 ; BARBAKC583_0022 .
GeneIDi 4684498.
KEGGi bbk:BARBAKC583_0022.
PATRICi 20536319. VBIBarBac6912_0022.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YAPSAFV.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci BBAC360095:GHRY-22-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiMDH_BARBK
AccessioniPrimary (citable) accession number: A1UQV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3