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A1UQU2 (AROE_BARBK) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase
EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:BARBAKC583_0006
OrganismBartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]
Taxonomic identifier360095 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

shikimate 3-dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Shikimate dehydrogenase HAMAP MF_00222
PRO_0000325102

Regions

Nucleotide binding135 – 1395NADP By similarity

Sites

Active site751Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
A1UQU2 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 88324C262B547741

FASTA29132,416
        10         20         30         40         50         60 
MVDLVDHKKI CSRVFVVGYP IHHSKSPKIH KFWLKYYGLQ GESVSEEVTV REFSNFIASI 

        70         80         90        100        110        120 
KKGNFLGGNV TSPHKQEAFR LADYKDGIAT AIGAANTLWI EGKKLLATNS DAYGFSANLD 

       130        140        150        160        170        180 
DFVPGWAGET ALVFGAGGAA RAIIYALKKR KFERIFLFNR TKKNADDLAE YFGKSTIKVY 

       190        200        210        220        230        240 
DWCSSCEKAR QADLIVNTTS MDMINFSERE NGAFFDFHKT KPTALVTDVV YTPLITPFLQ 

       250        260        270        280        290 
QAKAHGLKTV NGLGMLLHQA VPGFEKWFGV RPSVTKELRA AILEDMGENR G

« Hide

References

[1]Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000524 Genomic DNA. Translation: ABM45309.1.
RefSeqYP_988345.1. NC_008783.1.

3D structure databases

ProteinModelPortalA1UQU2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1UQU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4684935.
GenomeReviewsGene locus BARBAKC583_0006 in contig CP000524_GR.
KEGGbbk:BARBAKC583_0006.
NMPDRfig|360095.3.peg.982.
PATRIC20536287. VBIBarBac6912_0006.
TIGRBARBAKC583_0006.

Phylogenomic databases

eggNOGCOG0169.
HOGENOMHBG553408.
OMAFERWFGI.
ProtClustDBPRK00258.

Enzyme and pathway databases

BioCycBBAC360095:BARBAKC583_0006-MONOMER.

Family and domain databases

HAMAPMF_00222. Shikimate_DH_AroE.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00014.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. AroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_BARBK
AccessionPrimary (citable) accession number: A1UQU2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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