ID   A1UPI4_MYCSK            Unreviewed;       518 AA.
AC   A1UPI4;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   OrderedLocusNames=Mkms_5558 {ECO:0000313|EMBL:ABL94742.1};
OS   Mycobacterium sp. (strain KMS).
OG   Plasmid pMKMS01 {ECO:0000313|EMBL:ABL94742.1}.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=189918 {ECO:0000313|EMBL:ABL94742.1};
RN   [1] {ECO:0000313|EMBL:ABL94742.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KMS {ECO:0000313|EMBL:ABL94742.1};
RC   PLASMID=pMKMS01 {ECO:0000313|EMBL:ABL94742.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA   Richardson P.;
RT   "Complete sequence of plasmid pMKMS01 of Mycobacterium sp. KMS.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR   EMBL; CP000519; ABL94742.1; -; Genomic_DNA.
DR   AlphaFoldDB; A1UPI4; -.
DR   KEGG; mkm:Mkms_5558; -.
DR   HOGENOM; CLU_000288_63_44_11; -.
DR   OrthoDB; 5622056at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR   PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:ABL94742.1};
KW   Plasmid {ECO:0000313|EMBL:ABL94742.1};
KW   Transferase {ECO:0000313|EMBL:ABL94742.1}.
FT   DOMAIN          17..286
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          287..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  54696 MW;  E000EBDEFCB1D75C CRC64;
     MTAPEGQPPP PTHIAGYRVE RVLAVTAMAT VYLVHSPTLP RREVLKVLQP EHANGDHVRA
     QFLHEADITA GLEHPNIVRV FSRGETDTGQ LWIAMEYVEG TNAETALRDG QMTPERAVHI
     ITEVARALDY AHSHGVVHQD IKPSNFLIAA QKLPGGLDRV VLTDFGAALS PHSRGAGDGP
     MSATLAYSAP EVITGTAALD GRADVYSLAC TLFRLLTGEH PYPTDAGVGA TVKAHLDTTP
     PRVSDRLSWA SPQLDSVIAK ALAKNPADRY PTAGDFAAAA NAAPTLPLPL APVAPRDDRD
     EPPPRTELGG AESHGAAADF ISLLPHTRAV SQRRQLLAAI AVAGVLIVAL SVWLIGRGSD
     PPDTAPTAAP QTTSTAPPAA LEDLRRLLPS GYPADACTPA PSPDSATVIT CGPNTDPGGP
     RSATYTLAAG PEALRTTFDQ LVETTTVVVC PGNIQSPGPW RRNDTPAVTR GTVLCGLSNG
     RPRVVWTNDA QRLIADVQSD GPNDPRLDQL YAWWGTHS
//