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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:Mkms_5180
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000638 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001454201 – 171Peptide methionine sulfoxide reductase MsrAAdd BLAST171

Structurei

3D structure databases

ProteinModelPortaliA1UNG1
SMRiA1UNG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263863
KOiK07304
OMAiGYCAFVV
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

A1UNG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDHKKAILA GGCFWGMQDL IRKQPGVVST RVGYTGGQND HPTYRNHPGH
60 70 80 90 100
AESIEITYDP AQTDYRALLE FFFQIHDPTT KNRQGNDVGT SYRSAIFYVD
110 120 130 140 150
DEQKRVALDT IADVDASGLW PGKVVTEVTP AGEFWEAEPE HQDYLERMPW
160 170
GYTCHFPRPD WKLPKRADAK A
Length:171
Mass (Da):19,443
Last modified:February 6, 2007 - v1
Checksum:i17009E2D6DCCDBE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA Translation: ABL94369.1
RefSeqiWP_011562467.1, NC_008705.1

Genome annotation databases

EnsemblBacteriaiABL94369; ABL94369; Mkms_5180
GeneIDi32419616
KEGGimkm:Mkms_5180

Similar proteinsi

Entry informationi

Entry nameiMSRA_MYCSK
AccessioniPrimary (citable) accession number: A1UNG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health