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A1UMI0

- PANC_MYCSK

UniProt

A1UMI0 - PANC_MYCSK

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Protein

Pantothenate synthetase

Gene
panC, Mkms_4848
Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton donor By similarity
Binding sitei75 – 751Beta-alanine By similarity
Binding sitei75 – 751Pantoate By similarity
Binding sitei167 – 1671Pantoate By similarity
Binding sitei190 – 1901ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508ATP By similarity
Nucleotide bindingi161 – 1644ATP By similarity
Nucleotide bindingi198 – 2014ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP189918:GH4X-4896-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:Mkms_4848
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Pantothenate synthetaseUniRule annotationPRO_0000305489Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi189918.Mkms_4848.

Structurei

3D structure databases

ProteinModelPortaliA1UMI0.
SMRiA1UMI0. Positions 9-291.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UMI0-1 [UniParc]FASTAAdd to Basket

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MTARRPTRFA KGELNVYRAP RDVTDVTRAL RSTGRRVVLV PTMGALHEGH    50
LTLIRAAKRV QGAVVVVSIF VNPLQFGAGE DLDAYPRTLD DDLAALRAEG 100
VEIAFTPTVG DMYPDGTRTS VHPGPLGDDL EGASRPGHFA GVLTVVCKLL 150
HIVRPDRAFF GEKDYQQLVL IRQMVTDLNI DTKIVGVPTV READGLALSS 200
RNRYLDEVER EQAGALSAAL LAGMYAASNG AAATLDAARA VLDEVPAIEV 250
DYLQVRDPML GPVPHEGAAR LLVAARLGQT RLLDNIAVDI GASDGIDGHP 300
RVGSPDHQLP WRN 313
Length:313
Mass (Da):33,668
Last modified:February 6, 2007 - v1
Checksum:iF712971E5184A02D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL94038.1.
RefSeqiYP_940828.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL94038; ABL94038; Mkms_4848.
GeneIDi4616263.
KEGGimkm:Mkms_4848.
PATRICi18108752. VBIMycSp70743_5384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL94038.1 .
RefSeqi YP_940828.1. NC_008705.1.

3D structure databases

ProteinModelPortali A1UMI0.
SMRi A1UMI0. Positions 9-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189918.Mkms_4848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL94038 ; ABL94038 ; Mkms_4848 .
GeneIDi 4616263.
KEGGi mkm:Mkms_4848.
PATRICi 18108752. VBIMycSp70743_5384.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci MSP189918:GH4X-4896-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMS.

Entry informationi

Entry nameiPANC_MYCSK
AccessioniPrimary (citable) accession number: A1UMI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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