UniProtKB - A1UM81 (ACDH1_MYCSK)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Acetaldehyde dehydrogenase 1
Gene
Mkms_4748
Organism
Mycobacterium sp. (strain KMS)
Status
Functioni
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation
Catalytic activityi
Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 127 | Acyl-thioester intermediateUniRule annotation | 1 | |
Binding sitei | 282 | NADUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 15 | NADUniRule annotation | 4 | |
Nucleotide bindingi | 163 – 171 | NADUniRule annotation | 9 |
GO - Molecular functioni
- acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-EC
- NAD binding Source: InterPro
GO - Biological processi
- aromatic compound catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Aromatic hydrocarbons catabolism |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | Recommended name: Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)Alternative name(s): Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation |
Gene namesi | Ordered Locus Names:Mkms_4748 |
Organismi | Mycobacterium sp. (strain KMS) |
Taxonomic identifieri | 189918 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000387684 | 1 – 310 | Acetaldehyde dehydrogenase 1Add BLAST | 310 |
Structurei
3D structure databases
ProteinModelPortali | A1UM81 |
SMRi | A1UM81 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the acetaldehyde dehydrogenase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000052149 |
KOi | K04073 |
OMAi | TSAYVHK |
OrthoDBi | POG091H09NP |
Family and domain databases
HAMAPi | MF_01657 Ac_ald_DH_ac, 1 hit |
InterProi | View protein in InterPro IPR003361 Acetaldehyde_dehydrogenase IPR015426 Acetylaldehyde_DH_C IPR036291 NAD(P)-bd_dom_sf IPR000534 Semialdehyde_DH_NAD-bd |
Pfami | View protein in Pfam PF09290 AcetDehyd-dimer, 1 hit PF01118 Semialdhyde_dh, 1 hit |
PIRSFi | PIRSF015689 Actaldh_dh_actl, 1 hit |
SMARTi | View protein in SMART SM00859 Semialdhyde_dh, 1 hit |
SUPFAMi | SSF51735 SSF51735, 1 hit |
TIGRFAMsi | TIGR03215 ac_ald_DH_ac, 1 hit |
i Sequence
Sequence statusi: Complete.
A1UM81-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEKLQVAIV GSGNISTDLL YKLQRSEYLE PRWMIGIDPE SEGLARARKL
60 70 80 90 100
GLETSHEGVD WLLAQDDKPD LVFEATSAYV HRAAAPRYEE AGIRAIDLTP
110 120 130 140 150
AAVGPAVIPP ANLREHLDAP NVNMITCGGQ ATIPIVYAVT RAVTEQGGTV
160 170 180 190 200
PYAEIVASVS SSSAGPGTRA NIDEFTKTTS KGVQTIGGAA RGKAIIILNP
210 220 230 240 250
ADPPMIMRDT IFCAIPEDVD RDAIAQSIRD VVAEVQTYVP GYRLLNDPQF
260 270 280 290 300
DDPSINSGGQ AVVTTFVEVE GAGDYLPPYA GNLDIMTAAA AKVGEEIAKE
310
SLSLAGGAQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000518 Genomic DNA Translation: ABL93939.1 |
RefSeqi | WP_011562037.1, NC_008705.1 |
Genome annotation databases
EnsemblBacteriai | ABL93939; ABL93939; Mkms_4748 |
GeneIDi | 32422520 |
KEGGi | mkm:Mkms_4748 |
Similar proteinsi
Entry informationi
Entry namei | ACDH1_MYCSK | |
Accessioni | A1UM81Primary (citable) accession number: A1UM81 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 3, 2009 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 28, 2018 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |