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Protein

Acetaldehyde dehydrogenase 1

Gene

Mkms_4748

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127Acyl-thioester intermediateUniRule annotation1
Binding sitei282NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi163 – 171NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:Mkms_4748
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000638 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876841 – 310Acetaldehyde dehydrogenase 1Add BLAST310

Structurei

3D structure databases

ProteinModelPortaliA1UM81
SMRiA1UM81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149
KOiK04073
OMAiTSAYVHK
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

A1UM81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEKLQVAIV GSGNISTDLL YKLQRSEYLE PRWMIGIDPE SEGLARARKL
60 70 80 90 100
GLETSHEGVD WLLAQDDKPD LVFEATSAYV HRAAAPRYEE AGIRAIDLTP
110 120 130 140 150
AAVGPAVIPP ANLREHLDAP NVNMITCGGQ ATIPIVYAVT RAVTEQGGTV
160 170 180 190 200
PYAEIVASVS SSSAGPGTRA NIDEFTKTTS KGVQTIGGAA RGKAIIILNP
210 220 230 240 250
ADPPMIMRDT IFCAIPEDVD RDAIAQSIRD VVAEVQTYVP GYRLLNDPQF
260 270 280 290 300
DDPSINSGGQ AVVTTFVEVE GAGDYLPPYA GNLDIMTAAA AKVGEEIAKE
310
SLSLAGGAQA
Length:310
Mass (Da):32,743
Last modified:February 6, 2007 - v1
Checksum:i66FEDF3EFA394636
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA Translation: ABL93939.1
RefSeqiWP_011562037.1, NC_008705.1

Genome annotation databases

EnsemblBacteriaiABL93939; ABL93939; Mkms_4748
GeneIDi32422520
KEGGimkm:Mkms_4748

Similar proteinsi

Entry informationi

Entry nameiACDH1_MYCSK
AccessioniPrimary (citable) accession number: A1UM81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: February 6, 2007
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome