A1UM81 (ACDH1_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase 1
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1

Gene names

Ordered Locus Names:

Mkms_4748

Organism

Mycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]

Taxonomic identifier

189918 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Acetaldehyde dehydrogenase 1 HAMAP-Rule MF_01657		PRO_0000387684
Regions
	Nucleotide binding	12 – 15	4	NAD By similarity
	Nucleotide binding	163 – 171	9	NAD By similarity
Sites
	Active site	127	1	Acyl-thioester intermediate By similarity
	Binding site	282	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1UM81 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 66FEDF3EFA394636	FASTA	310	32,743
	10 20 30 40 50 60 MPEKLQVAIV GSGNISTDLL YKLQRSEYLE PRWMIGIDPE SEGLARARKL GLETSHEGVD 70 80 90 100 110 120 WLLAQDDKPD LVFEATSAYV HRAAAPRYEE AGIRAIDLTP AAVGPAVIPP ANLREHLDAP 130 140 150 160 170 180 NVNMITCGGQ ATIPIVYAVT RAVTEQGGTV PYAEIVASVS SSSAGPGTRA NIDEFTKTTS 190 200 210 220 230 240 KGVQTIGGAA RGKAIIILNP ADPPMIMRDT IFCAIPEDVD RDAIAQSIRD VVAEVQTYVP 250 260 270 280 290 300 GYRLLNDPQF DDPSINSGGQ AVVTTFVEVE GAGDYLPPYA GNLDIMTAAA AKVGEEIAKE 310 SLSLAGGAQA

References

[1]

"Complete sequence of chromosome of Mycobacterium sp. KMS." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KMS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000518 Genomic DNA. Translation: ABL93939.1.
RefSeq	YP_940729.1. NC_008705.1.
3D structure databases
ProteinModelPortal	A1UM81.
ModBase	Search...
Protein-protein interaction databases
STRING	189918.Mkms_4748.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABL93939; ABL93939; Mkms_4748.
GeneID	4616163.
KEGG	mkm:Mkms_4748.
PATRIC	18108548. VBIMycSp70743_5282.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HOG000052149.
KO	K04073.
OMA	HAMIQEV.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	MSP189918:GH4X-4805-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH1_MYCSK

Accession

Primary (citable) accession number: A1UM81

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program