Mkms_4748

Functionⁱ

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD⁺ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityⁱ

Acetaldehyde + CoA + NAD⁺ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	127	Acyl-thioester intermediateUniRule annotation		1
Binding siteⁱ	282	NADUniRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	12 – 15	NADUniRule annotation		4
Nucleotide bindingⁱ	163 – 171	NADUniRule annotation		9

GO - Molecular functionⁱ

acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-EC
NAD binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

aromatic compound catabolic process Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD

Enzyme and pathway databases

BioCycⁱ	MSP189918:GH4X-4768-MONOMER.

BioCycⁱ

MSP189918:GH4X-4768-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation) Alternative name(s): Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesⁱ	Ordered Locus Names:Mkms_4748
Organismⁱ	Mycobacterium sp. (strain KMS)
Taxonomic identifierⁱ	189918 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium
Proteomesⁱ	UP000000638 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000387684	1 – 310	Acetaldehyde dehydrogenase 1Add BLAST		310

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1UM81.
SMRⁱ	A1UM81.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000052149.
KEGG Orthology (KO) More...KOⁱ	K04073.
OMAⁱ	TSAYVHK.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H09NP.

Family and domain databases

HAMAPⁱ	MF_01657. Ac_ald_DH_ac. 1 hit.
InterProⁱ	View protein in InterPro IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit.
PIRSFⁱ	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTⁱ	View protein in SMART SM00859. Semialdhyde_dh. 1 hit.
SUPFAMⁱ	SSF51735. SSF51735. 1 hit.
TIGRFAMsⁱ	TIGR03215. ac_ald_DH_ac. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A1UM81-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPEKLQVAIV GSGNISTDLL YKLQRSEYLE PRWMIGIDPE SEGLARARKL 
        60         70         80         90        100
GLETSHEGVD WLLAQDDKPD LVFEATSAYV HRAAAPRYEE AGIRAIDLTP 
       110        120        130        140        150
AAVGPAVIPP ANLREHLDAP NVNMITCGGQ ATIPIVYAVT RAVTEQGGTV 
       160        170        180        190        200
PYAEIVASVS SSSAGPGTRA NIDEFTKTTS KGVQTIGGAA RGKAIIILNP 
       210        220        230        240        250
ADPPMIMRDT IFCAIPEDVD RDAIAQSIRD VVAEVQTYVP GYRLLNDPQF 
       260        270        280        290        300
DDPSINSGGQ AVVTTFVEVE GAGDYLPPYA GNLDIMTAAA AKVGEEIAKE 
       310
SLSLAGGAQA

Length:310

Mass (Da):32,743

Last modified:February 6, 2007 - v1

Checksum:ⁱ66FEDF3EFA394636

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000518 Genomic DNA. Translation: ABL93939.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011562037.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABL93939; ABL93939; Mkms_4748.
GeneIDⁱ	32422520.
KEGGⁱ	mkm:Mkms_4748.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000518 Genomic DNA. Translation: ABL93939.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011562037.1. NC_008705.1.

3D structure databases

ProteinModelPortalⁱ	A1UM81.
SMRⁱ	A1UM81.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABL93939; ABL93939; Mkms_4748.
GeneIDⁱ	32422520.
KEGGⁱ	mkm:Mkms_4748.

Phylogenomic databases

HOGENOMⁱ	HOG000052149.
KEGG Orthology (KO) More...KOⁱ	K04073.
OMAⁱ	TSAYVHK.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H09NP.

Enzyme and pathway databases

BioCycⁱ	MSP189918:GH4X-4768-MONOMER.

BioCycⁱ

MSP189918:GH4X-4768-MONOMER.

Family and domain databases

HAMAPⁱ	MF_01657. Ac_ald_DH_ac. 1 hit.
InterProⁱ	View protein in InterPro IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit.
PIRSFⁱ	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTⁱ	View protein in SMART SM00859. Semialdhyde_dh. 1 hit.
SUPFAMⁱ	SSF51735. SSF51735. 1 hit.
TIGRFAMsⁱ	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACDH1_MYCSK
Accessionⁱ	A1UM81Primary (citable) accession number: A1UM81
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
	Last sequence update:	February 6, 2007
	Last modified:	July 5, 2017
	This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - A1UM81 (ACDH1_MYCSK)

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Acetaldehyde dehydrogenase 1

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Functionⁱ

Catalytic activityⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1UM81 (ACDH1_MYCSK)

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Acetaldehyde dehydrogenase 1

Mkms_4748

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ