Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenylosuccinate lyase

Gene

Mkms_4654

Organism
Mycobacterium sp. (strain KMS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' AMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciMSP189918:GH4X-4701-MONOMER.
UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Ordered Locus Names:Mkms_4654Imported
OrganismiMycobacterium sp. (strain KMS)Imported
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi189918.Mkms_4654.

Structurei

3D structure databases

ProteinModelPortaliA1ULY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0015.
HOGENOMiHOG000033913.
KOiK01756.
OMAiIHSQLDH.
OrthoDBiEOG686NDB.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1ULY7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIPNVLANR YASEDMVAIW SPEAKIVAER RLWLAVLRAQ IELGMGNTVV
60 70 80 90 100
PDGVVADYER VLDQVDLASI AARERVTRHD VKARIEEFNA LAGHEHVHKG
110 120 130 140 150
MTSRDLTENV EQLQIRRSLE LVHAHGVAVV ARLAEKAVSY RDLVMAGRSH
160 170 180 190 200
NVAAQATTLG KRFASAAEET LLALQRVEEL IARYPLRGIK GPMGTAQDML
210 220 230 240 250
DLFGGDTAKL ADLERRVAEF LGFRDVFTSV GQVYPRSLDH DVVSALVQLG
260 270 280 290 300
AGPSSLAHTI RLMAGHELVT EGFAPGQVGS SAMPHKMNTR SCERVNGLQV
310 320 330 340 350
VLRGYGSMAA ELAGAQWNEG DVFCSVVRRV ALPDAFFAID GQTETFLTVL
360 370 380 390 400
DEFGAYPAVI QRELDRYLPF LATTRILIAA VRAGVGRETA HEVIKEHAVA
410 420 430 440 450
VALAMREKGQ EPDLLDRLAA DPRLPLDRVA LEDALADKQA FSGAAGDQVD
460 470
RVAQAVDELV SRYPEAAKYT SGAIL
Length:475
Mass (Da):51,696
Last modified:February 6, 2007 - v1
Checksum:i082A0E551D7FE86B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL93845.1.
RefSeqiWP_011768377.1. NC_008705.1.
YP_940635.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL93845; ABL93845; Mkms_4654.
GeneIDi4612602.
KEGGimkm:Mkms_4654.
PATRICi18108358. VBIMycSp70743_5188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL93845.1.
RefSeqiWP_011768377.1. NC_008705.1.
YP_940635.1. NC_008705.1.

3D structure databases

ProteinModelPortaliA1ULY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189918.Mkms_4654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL93845; ABL93845; Mkms_4654.
GeneIDi4612602.
KEGGimkm:Mkms_4654.
PATRICi18108358. VBIMycSp70743_5188.

Phylogenomic databases

eggNOGiCOG0015.
HOGENOMiHOG000033913.
KOiK01756.
OMAiIHSQLDH.
OrthoDBiEOG686NDB.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.
BioCyciMSP189918:GH4X-4701-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR019468. AdenyloSucc_lyase_C.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10397. ADSL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SMARTiSM00998. ADSL_C. 1 hit.
[Graphical view]
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMSImported.

Entry informationi

Entry nameiA1ULY7_MYCSK
AccessioniPrimary (citable) accession number: A1ULY7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.