Skip Header

Contribute Send feedback
Read comments (?) or add your own

A1ULW1 (A1ULW1_MYCSK) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:Mkms_4628
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site171For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2581Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4041Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4601Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4631Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
A1ULW1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 92A0BD1EF4EBC4F3

FASTA51154,459
        10         20         30         40         50         60 
MSGHDDIEPE NDPREECGVF GVWAPGEDVA KLTYYGLYAL QHRGQEAAGI AVADGSQVLV 

        70         80         90        100        110        120 
FKDLGLVSQV FDEPTLAAMH GHVAIGHCRY STTGSTTWEN AQPVFRNTLA GTGVAVGHNG 

       130        140        150        160        170        180 
NLVNTTELAA RARDAGLING RTPGAATTDS DILGALLAHG AADATVEQAA LELLPTVRGA 

       190        200        210        220        230        240 
FCLTFMDENT LYAARDPYGV RPLSLGRLDR GWVVASETAA LDIVGASFVR DIEPGELLAI 

       250        260        270        280        290        300 
DADGVRSTRF ANPTPKSCVF EYVYLARPDS TLAGRSVHAT RVDIGRRLAS EMPVEADLVI 

       310        320        330        340        350        360 
GVPESGTPAA VGYAQGSGIP YGQGLMKNAY VGRTFIQPSQ TIRQLGIRLK LNPLKEVIRG 

       370        380        390        400        410        420 
KRLIVVDDSI VRGNTQRALI RMLREAGALE VHVRIASPPV RWPCFYGIDF ATPAELIANG 

       430        440        450        460        470        480 
AEDEDQMLDA VRRAIGADTL GYISQQGMIA ATEQPASRLC SACFDGNYPI ELPGESALGK 

       490        500        510 
NVIEQMLATA ARSGIPLEKV DNDNASALRR P

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL93819.1.
RefSeqYP_940609.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1ULW1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1ULW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000053446; EBMYCP00000051670; EBMYCG00000053441.
GeneID4612576.
GenomeReviewsGene locus Mkms_4628 in contig CP000518_GR.
KEGGmkm:Mkms_4628.
PATRIC18108308. VBIMycSp70743_5163.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0034.
GeneTreeEBGT00050000016850.
HOGENOMHBG392416.
OMAVWAPGEE.
ProtClustDBPRK07847.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 2 hits.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1ULW1_MYCSK
AccessionPrimary (citable) accession number: A1ULW1
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info