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A1UL88

- PUR9_MYCSK

UniProt

A1UL88 - PUR9_MYCSK

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Mkms_4405
Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciMSP189918:GH4X-4447-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Mkms_4405
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018912Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi189918.Mkms_4405.

Structurei

3D structure databases

ProteinModelPortaliA1UL88.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiHRRAHAC.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UL88-1 [UniParc]FASTAAdd to Basket

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MSGDQGQAGA KRPIRRALIS VYDKTGLIDL ARGLHEAGVD IVSTGSTAKT    50
IADKGIPVTP VEFVTGFPEV LDGRVKTLHP HIHAGLLADT RKPEHVEALA 100
KLGIAPFDLV VVNLYPFSET VESGASVDEC VEQIDIGGPS MVRAAAKNHP 150
SVAVVVEPNG YDGVLAAVRT GGFTLAERKI LASLAFRHTA EYDVAVASWM 200
GSTLAPEEPA QKLPAWVGGT WRRAAVLRYG ENPHQQAALY RDATAWPGLA 250
QAEQLHGKEM SYNNYTDADA AWRAAFDHEE ICVAIIKHAN PCGIAISSVS 300
VADAHRKAHE CDPLSAFGGV IATNSSVSVE MAETVADIFT EVIVAPAYEP 350
GAVEILSRKK NIRILVAAQP PTTGTELRPI SGGLLLQQRD ALDADGDDPV 400
NWTLATGEPA DPATLANLKF AWRSCRAVKS NAIVVVADGA TVGVGMGQVN 450
RVDAARLAVQ RAGDRVRGAV AASDAFFPFP DGLETLTEAG VKAIVHPGGS 500
MRDDVVTEAA AKAGISLYLT GARHFAH 527
Length:527
Mass (Da):55,533
Last modified:February 6, 2007 - v1
Checksum:i47F4078911419553
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL93596.1.
RefSeqiYP_940386.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL93596; ABL93596; Mkms_4405.
GeneIDi4612348.
KEGGimkm:Mkms_4405.
PATRICi18107830. VBIMycSp70743_4929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL93596.1 .
RefSeqi YP_940386.1. NC_008705.1.

3D structure databases

ProteinModelPortali A1UL88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189918.Mkms_4405.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL93596 ; ABL93596 ; Mkms_4405 .
GeneIDi 4612348.
KEGGi mkm:Mkms_4405.
PATRICi 18107830. VBIMycSp70743_4929.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi HRRAHAC.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci MSP189918:GH4X-4447-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMS.

Entry informationi

Entry nameiPUR9_MYCSK
AccessioniPrimary (citable) accession number: A1UL88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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