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A1UL70

- MPRA_MYCSK

UniProt

A1UL70 - MPRA_MYCSK

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Protein

Response regulator MprA

Gene
mprA, Mkms_4387
Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. phosphorelay response regulator activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. response to stress Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response, Transcription, Transcription regulation, Two-component regulatory system, Virulence

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciMSP189918:GH4X-4429-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Response regulator MprA
Alternative name(s):
Mycobacterial persistence regulator A
Gene namesi
Name:mprA
Ordered Locus Names:Mkms_4387
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Response regulator MprAPRO_0000308425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 4814-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated and dephosphorylated by MprB By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi189918.Mkms_4387.

Structurei

3D structure databases

ProteinModelPortaliA1UL70.
SMRiA1UL70. Positions 3-227.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 118115Response regulatoryAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
KOiK07669.
OMAiCKAIRSK.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1UL70-1 [UniParc]FASTAAdd to Basket

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MPVRILVVDD DRAVRESLRR SLSFNGYSVE LAQDGVEALD LIANNRPDAV    50
VLDVMMPRLD GLEVCRQLRS TGDDLPILVL TARDSVSERV AGLDAGADDY 100
LPKPFALEEL LARMRALLRR TSPDEGPDSP ALTFLDLTLD PVTREVTRGS 150
RQISLTRTEF ALLEMLIANP RRVLTRSRIL EEVWGFDFPT SGNALEVYIG 200
YLRRKTEASG EPRLIHTVRG VGYVLRETPP 230
Length:230
Mass (Da):25,698
Last modified:February 6, 2007 - v1
Checksum:iFDAC1A698D334B57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL93578.1.
RefSeqiYP_940368.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL93578; ABL93578; Mkms_4387.
GeneIDi4612330.
KEGGimkm:Mkms_4387.
PATRICi18107794. VBIMycSp70743_4911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL93578.1 .
RefSeqi YP_940368.1. NC_008705.1.

3D structure databases

ProteinModelPortali A1UL70.
SMRi A1UL70. Positions 3-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189918.Mkms_4387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL93578 ; ABL93578 ; Mkms_4387 .
GeneIDi 4612330.
KEGGi mkm:Mkms_4387.
PATRICi 18107794. VBIMycSp70743_4911.

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034815.
KOi K07669.
OMAi CKAIRSK.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci MSP189918:GH4X-4429-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMS.

Entry informationi

Entry nameiMPRA_MYCSK
AccessioniPrimary (citable) accession number: A1UL70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi