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A1UL70 (MPRA_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Response regulator MprA
Alternative name(s):
Mycobacterial persistence regulator A
Gene names
Name:mprA
Ordered Locus Names:Mkms_4387
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region By similarity.

Subcellular location

Cytoplasm Potential.

Post-translational modification

Phosphorylated and dephosphorylated by MprB By similarity.

Sequence similarities

Contains 1 response regulatory domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230Response regulator MprA
PRO_0000308425

Regions

Domain4 – 118115Response regulatory

Amino acid modifications

Modified residue4814-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1UL70 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: FDAC1A698D334B57

FASTA23025,698
        10         20         30         40         50         60 
MPVRILVVDD DRAVRESLRR SLSFNGYSVE LAQDGVEALD LIANNRPDAV VLDVMMPRLD 

        70         80         90        100        110        120 
GLEVCRQLRS TGDDLPILVL TARDSVSERV AGLDAGADDY LPKPFALEEL LARMRALLRR 

       130        140        150        160        170        180 
TSPDEGPDSP ALTFLDLTLD PVTREVTRGS RQISLTRTEF ALLEMLIANP RRVLTRSRIL 

       190        200        210        220        230 
EEVWGFDFPT SGNALEVYIG YLRRKTEASG EPRLIHTVRG VGYVLRETPP 

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000518 Genomic DNA. Translation: ABL93578.1.
RefSeqYP_940368.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UL70.
SMRA1UL70. Positions 3-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING189918.Mkms_4387.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL93578; ABL93578; Mkms_4387.
GeneID4612330.
KEGGmkm:Mkms_4387.
PATRIC18107794. VBIMycSp70743_4911.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034815.
KOK07669.
OMADFMGDSN.
OrthoDBEOG6G4VQG.
ProtClustDBCLSK790869.

Enzyme and pathway databases

BioCycMSP189918:GH4X-4429-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPRA_MYCSK
AccessionPrimary (citable) accession number: A1UL70
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families