A1UKP2 (COAA_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	Mkms_4208

Organism

Mycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]

Taxonomic identifier

189918 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Pantothenate kinase HAMAP MF_00215		PRO_1000043230
Regions
	Nucleotide binding	97 – 104	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A1UKP2 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: A0618C6D623262B4	FASTA	312	35,477
	10 20 30 40 50 60 MARLSEPSPY VEFDRTQWRA LRMSTPLKLT EDELKKLRGL GEKLDLLEVE EVYLPLARLI 70 80 90 100 110 120 HLQVAARQRL FAATSEFLGE PQQNPDRPVP FIIGVAGSVA VGKSTTARVL QALLARWGNH 130 140 150 160 170 180 ARVDLVTTDG FLYPNAELGR RNIMHRKGFP ESYDRRALMR FVTAVKSGAD YACAPVYSHL 190 200 210 220 230 240 LYDIVPGEKQ VIRHPDILIL EGLNVLQTGP ALMVSDLFDF SVYVDARLED IEGWYISRFL 250 260 270 280 290 300 TMRSTAFADP ASHFHHYATL TDEQAVFAAR DIWHSINRPN LIENILPTRP RATLVLRKDA 310 DHAINRLRLR KL

References

[1]

"Complete sequence of chromosome of Mycobacterium sp. KMS." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KMS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000518 Genomic DNA. Translation: ABL93400.1.
RefSeq	YP_940190.1. NC_008705.1.
3D structure databases
ProteinModelPortal	A1UKP2.
SMR	A1UKP2. Positions 5-312.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UKP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000057527; EBMYCP00000055751; EBMYCG00000057522.
GeneID	4612148.
GenomeReviews	Gene locus Mkms_4208 in contig CP000518_GR.
KEGG	mkm:Mkms_4208.
PATRIC	18107428. VBIMycSp70743_4731.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
GeneTree	EBGT00050000016369.
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	MSP189918:MKMS_4208-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_MYCSK

Accession

Primary (citable) accession number: A1UKP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program