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Protein

1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase

Gene

mshB

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371ZincUniRule annotation
Metal bindingi40 – 401ZincUniRule annotation
Metal bindingi171 – 1711ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMSP189918:GH4X-4148-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylaseUniRule annotation (EC:3.5.1.103UniRule annotation)
Short name:
GlcNAc-Ins deacetylaseUniRule annotation
Alternative name(s):
N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Gene namesi
Name:mshBUniRule annotation
Ordered Locus Names:Mkms_4109
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000638 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3083081D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylasePRO_0000400203Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1UKE3.
SMRiA1UKE3. Positions 24-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MshB deacetylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241173.
KOiK15525.
OMAiMMGLATN.
OrthoDBiPOG091H08W5.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UKE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFADSAVACV ISALRAVGVD SPLMSELVPR LLFVHAHPDD ETLTTGGTIA
60 70 80 90 100
HYVRRGADVR VVTCTLGEEG EVIGEQYAQL AVDHADQLGG YRIAELTAAL
110 120 130 140 150
AALGVDAPHF LGGPGHWRDS GMADTPARHQ PRFVDADMAE AAGLLAAILD
160 170 180 190 200
DFRPHVVVTY DPDGGYGHPD HVQTHRVTTA AVERAQWQVP KFYWTVMSRS
210 220 230 240 250
GMGDAFAVAR DVPEEWLQVS VDDVPFLYTD DRIDAVVDVS DSIEAKVAAM
260 270 280 290 300
RAHATQISVA ANGQSCALSN NIAMPIPGVE HYVLVSGAPG PRDARGWETD

LLAGVNLA
Length:308
Mass (Da):32,882
Last modified:February 6, 2007 - v1
Checksum:iEC710FDE8C0A7510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL93301.1.
RefSeqiWP_011561412.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL93301; ABL93301; Mkms_4109.
KEGGimkm:Mkms_4109.
PATRICi18107232. VBIMycSp70743_4633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL93301.1.
RefSeqiWP_011561412.1. NC_008705.1.

3D structure databases

ProteinModelPortaliA1UKE3.
SMRiA1UKE3. Positions 24-305.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL93301; ABL93301; Mkms_4109.
KEGGimkm:Mkms_4109.
PATRICi18107232. VBIMycSp70743_4633.

Phylogenomic databases

HOGENOMiHOG000241173.
KOiK15525.
OMAiMMGLATN.
OrthoDBiPOG091H08W5.

Enzyme and pathway databases

BioCyciMSP189918:GH4X-4148-MONOMER.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
HAMAPiMF_01696. MshB. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
IPR017810. Mycothiol_biosynthesis_MshB.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.
TIGRFAMsiTIGR03445. mycothiol_MshB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHB_MYCSK
AccessioniPrimary (citable) accession number: A1UKE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.