A1UK27 (CYSD_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sulfate adenylyltransferase subunit 2
EC=2.7.7.4

Alternative name(s):
ATP-sulfurylase small subunit
Sulfate adenylate transferase
Short name=SAT

Gene names

Name:	cysD
Ordered Locus Names:	Mkms_3993

Organism

Mycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]

Taxonomic identifier

189918 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + sulfate = diphosphate + adenylyl sulfate. HAMAP MF_00064
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. HAMAP MF_00064
Subunit structure	Heterodimer composed of CysD, the smaller subunit, and CysN By similarity.
Sequence similarities	Belongs to the PAPS reductase family. CysD subfamily.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate reduction Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW sulfate adenylyltransferase (ATP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Sulfate adenylyltransferase subunit 2 HAMAP MF_00064		PRO_1000092210

Sequences

	Sequence		Length	Mass (Da)
	A1UK27 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: EBA28E7772AFCF98	FASTA	309	34,950
	10 20 30 40 50 60 MTAAHVAAPE PGQYELSHLR LLEAEAIHII REVAAEFERP VLLFSGGKDS IVMLHLAIKA 70 80 90 100 110 120 FAPARLPFPV MHVDTGHNFD EVISTRDRLV AENGVRLVVA SVQEDIDAGR VVDNGPSRNP 130 140 150 160 170 180 LQTITLLRAI RENRFDAAFG GARRDEEKAR AKERVFSFRD EFGQWDPKAQ RPELWNIYNG 190 200 210 220 230 240 RHRKGEHIRV FPLSNWTEYD IWAYIGAEGI TLPGIYYAHT RPVFQRDGML LAVHPYMQPR 250 260 270 280 290 300 DDEEVFETSV RFRTVGDVTC TGCVESTAST VEDIIAETAV SRLTERGATR ADDRISEAGM EDRKREGYF

References

[1]

"Complete sequence of chromosome of Mycobacterium sp. KMS." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KMS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000518 Genomic DNA. Translation: ABL93185.1.
RefSeq	YP_939975.1. NC_008705.1.
3D structure databases
ProteinModelPortal	A1UK27.
SMR	A1UK27. Positions 15-218.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UK27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000054834; EBMYCP00000053058; EBMYCG00000054829.
GeneID	4611933.
GenomeReviews	Gene locus Mkms_3993 in contig CP000518_GR.
KEGG	mkm:Mkms_3993.
PATRIC	18106996. VBIMycSp70743_4515.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0175.
GeneTree	EBGT00050000016335.
HOGENOM	HBG758022.
OMA	NYPEVIQ.
ProtClustDB	PRK05253.
Enzyme and pathway databases
BioCyc	MSP189918:MKMS_3993-MONOMER.
Family and domain databases
HAMAP	MF_00064. Sulf_adenylyltr_sub2. [Tree]
InterPro	IPR002500. PAPS_reduct. IPR014729. Rossmann-like_a/b/a_fold. IPR011784. SO4_adenylTrfase_ssu. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KO	K00957.
Pfam	PF01507. PAPS_reduct. 1 hit. [Graphical view]
PIRSF	PIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMs	TIGR02039. CysD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSD_MYCSK

Accession

Primary (citable) accession number: A1UK27

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program