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A1UHM8 (A1UHM8_MYCSK) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malto-oligosyltrehalose trehalohydrolase PIRNR PIRNR006337
Short name=MTHase PIRNR PIRNR006337
EC=3.2.1.141 PIRNR PIRNR006337
Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase PIRNR PIRNR006337
Maltooligosyl trehalose trehalohydrolase PIRNR PIRNR006337
Gene names
Ordered Locus Names:Mkms_3142
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan. PIRNR PIRNR006337

Pathway

Glycan biosynthesis; trehalose biosynthesis. PIRNR PIRNR006337

Subcellular location

Cytoplasm By similarity PIRSR PIRSR006337-1.

Sequence similarities

Belongs to the glycosyl hydrolase 13 family. PIRNR PIRNR006337

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2481Nucleophile By similarity PIRSR PIRSR006337-1
Active site2851Proton donor By similarity PIRSR PIRSR006337-1
Site3811Transition state stabilizer By similarity PIRSR PIRSR006337-3

Sequences

Sequence LengthMass (Da)Tools
A1UHM8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: BF90731B18B08ADC

FASTA58063,917
        10         20         30         40         50         60 
MPEFAVWAPL PERVRLDVEG SLHPMTCGDD GWWRIEVDAA PDARYGFVLD DDPKVLPDPR 

        70         80         90        100        110        120 
SPRQPDGVHE RSQLWQPAPD AWTDGAWAGR KIEGSEKGQV IYELHTGTFT PEGTFDAAIG 

       130        140        150        160        170        180 
KLDHLVDLGV DFVELMPVNA FGGTHGWGYD GVLWYAVHEP YGGPDALIRL IDACHSRGLG 

       190        200        210        220        230        240 
VLIDAVFNHL GPSGNYLPKF GPYLSSGSNP WGESINIADA GADEVRRYIL DCALRWMRDF 

       250        260        270        280        290        300 
HADGLRLDAV HALVDTTAIH ILEELSAETD ALADELGRPL SLIAESDMND PRLITPRDQG 

       310        320        330        340        350        360 
GLGMTAQWDD DIHHAIHAAV SGETQGYYGD WGTVEALAQT LRNGYFHAGT FSSFRNRRHG 

       370        380        390        400        410        420 
RPLDTATIPA TRLLAYTLTH DQVGNRAVGD RPSQNLDTGQ LAVKAALALG SPYTAMLFMG 

       430        440        450        460        470        480 
EEWGSSSPFQ FFSSHPEPEL ARATAEGRKR EFAEHGWDAD EIPDPQDPQT FLRSKLKWDE 

       490        500        510        520        530        540 
IDDGDHGRLR ALYRELIALR HNEPDLADPW LDHLRIDYDE AQRWIVMHRG SLSIACNLGA 

       550        560        570        580 
DAVTVPVTGD VVLAWGEPAP EGDGMSLAGH SFAVVRTQSR

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL92336.1.
RefSeqYP_939126.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UHM8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1UHM8.

Protein family/group databases

CAZyCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000057105; EBMYCP00000055329; EBMYCG00000057100.
GeneID4610977.
GenomeReviewsGene locus Mkms_3142 in contig CP000518_GR.
KEGGmkm:Mkms_3142.
PATRIC18105266. VBIMycSp70743_3664.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0296.
GeneTreeEBGT00050000016657.
HOGENOMHBG367595.
OMAEGFVYQG.
ProtClustDBCLSK799816.

Family and domain databases

InterProIPR015902. Alpha_amylase.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_subgr_catalytic.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR022567. Maltooligo_trehalose_bac_C.
IPR012768. Trehalose_TreZ.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 2 hits.
G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KOK01236.
PANTHERPTHR10357. Alpha_amylase. 1 hit.
PTHR10357:SF21. PTHR10357:SF21. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view]
PIRSFPIRSF006337. Trehalose_TreZ. 1 hit.
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
SSF81296. Ig_E-set. 1 hit.
TIGRFAMsTIGR02402. Trehalose_TreZ. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA1UHM8_MYCSK
AccessionPrimary (citable) accession number: A1UHM8
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info