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A1UHK7 (HIS8_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9
Alternative name(s):
Imidazole acetol-phosphate transaminase
Gene names
Name:hisC
Ordered Locus Names:Mkms_3121
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP-Rule MF_01023

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP-Rule MF_01023

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Histidinol-phosphate aminotransferase HAMAP-Rule MF_01023
PRO_0000319777

Amino acid modifications

Modified residue2321N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1UHK7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C605EAF18A2599B7

FASTA37740,678
        10         20         30         40         50         60 
MTVGERITLA DLPLRDDLRG KSPYGAPQLQ VPVRLNTNEN PHPPSQALVD DVTRSVGEAA 

        70         80         90        100        110        120 
AELHRYPDRD AVALRSDLAD YLNLRTGVEL SVENLWAANG SNEVLQQLLQ AFGGPGRSAI 

       130        140        150        160        170        180 
GFVPSYSMHP IIADATRTEW LQALRADDFG LDVDTAVREI AARRPDLVFV TSPNNPSGQS 

       190        200        210        220        230        240 
VPLEDLRRLL DAMETGILIL DEAYGEFSSQ PSGVALIDQY PTKLVVSRTM SKAFAFAGGR 

       250        260        270        280        290        300 
LGYLVAAPAV IEAMLLVRLP YHLSSLTQAA ARAALRHADD TLASVATLIA ERDRVANGLS 

       310        320        330        340        350        360 
QLGFRVVPSD ANFILFGEFA DAPATWRRYL DQGVLIRDVG IPGYLRTTIG LAEENDALLT 

       370 
ASARLVETEL AATLGAL

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL92315.1.
RefSeqYP_939105.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UHK7.
SMRA1UHK7. Positions 6-370.
ModBaseSearch...

Protein-protein interaction databases

STRING189918.Mkms_3121.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL92315; ABL92315; Mkms_3121.
GeneID4610956.
KEGGmkm:Mkms_3121.
PATRIC18105224. VBIMycSp70743_3643.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0079.
HOGENOMHOG000288510.
KOK00817.
OMAGRSAMGF.
ProtClustDBPRK03317.

Enzyme and pathway databases

BioCycMSP189918:GH4X-3178-MONOMER.
UniPathwayUPA00031; UER00012.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_01023. HisC_aminotrans_2.
InterProIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR005861. HisP_aminotrans.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01141. hisC. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS8_MYCSK
AccessionPrimary (citable) accession number: A1UHK7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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