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A1UHJ6 (TRPC_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48
Gene names
Name:trpC
Ordered Locus Names:Mkms_3110
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B

Sequence similarities

Belongs to the TrpC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Indole-3-glycerol phosphate synthase HAMAP MF_00134_B
PRO_1000018503

Sequences

Sequence LengthMass (Da)Tools
A1UHJ6 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 90379122A939E483

FASTA27228,666
        10         20         30         40         50         60 
MSSATVLDSI IEGVRADVAA REAVVSLTEI KERAQRAKPP LDVMAALREP GIGVIAEVKR 

        70         80         90        100        110        120 
ASPSRGALAQ IGDPADLARA YQDGGARVIS VLTEQRRFNG SLDDLDAVRA AVSIPVLRKD 

       130        140        150        160        170        180 
FIVRPYQIHE ARAHGADMLL LIVAALEQPV LESLLERTES LGMTALVEVH TEAEADRALQ 

       190        200        210        220        230        240 
AGARVIGVNA RNLKTLEVDR DCFARIAPGL PSNVIRIAES GVRGPADLLA YAGAGADAVL 

       250        260        270 
VGEGLVTSRD PRSAVADLVT AGTHPSCPKP SR

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL92304.1.
RefSeqYP_939094.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UHJ6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1UHJ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000057804; EBMYCP00000056028; EBMYCG00000057799.
GeneID4610945.
GenomeReviewsGene locus Mkms_3110 in contig CP000518_GR.
KEGGmkm:Mkms_3110.
PATRIC18105200. VBIMycSp70743_3631.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0134.
GeneTreeEBGT00050000017090.
HOGENOMHBG540956.
OMAMRKDDVT.
ProtClustDBPRK00278.

Enzyme and pathway databases

BioCycMSP189918:MKMS_3110-MONOMER.

Family and domain databases

HAMAPMF_00134_B. IGPS_B.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01609.
PfamPF00218. IGPS. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
PROSITEPS00614. IGPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPC_MYCSK
AccessionPrimary (citable) accession number: A1UHJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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