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A1UHA4 (A1UHA4_MYCSK) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phenylalanine--tRNA ligase alpha chain HAMAP MF_00281
EC=6.1.1.20 HAMAP MF_00281
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha chain HAMAP MF_00281
Gene names
Name:pheS HAMAP MF_00281
Ordered Locus Names:Mkms_3018
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). HAMAP MF_00281

Cofactor

Binds 2 magnesium ions per tetramer By similarity. HAMAP MF_00281

Subunit structure

Tetramer of two alpha and two beta chains By similarity. HAMAP MF_00281

Subcellular location

Cytoplasm By similarity HAMAP MF_00281.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily. HAMAP MF_00281

Sequences

Sequence LengthMass (Da)Tools
A1UHA4 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: CE9F5AF737D85A71

FASTA34437,685
        10         20         30         40         50         60 
MAGNLSEEAL TEAVDAARLA FDSAADLDAL ARAKTEHLGD RSPIAVARQS LGSLPKTERA 

        70         80         90        100        110        120 
DAGKRVNVAR SDAQRSYDER LAELRAERDA AVLVAERIDV TLPSTRQPVG ARHPITILAE 

       130        140        150        160        170        180 
NIADTFVAMG WELAEGPEVE TEQFNFDALN FPPDHPARSE QDTFYVAPDG SRQVLRTHTS 

       190        200        210        220        230        240 
PVQIRALLER DLPVYIISIG RTFRTDELDA THTPVFHQVE GLAVDRGLTM AHLRGTLDAF 

       250        260        270        280        290        300 
ARAQFGPQGG TRFRPHFFPF TEPSAEVDVW FPGKKGGPGW VEWGGCGMVN PNVLRACGID 

       310        320        330        340 
PDEYSGFAFG MGLERTLQFR NGIPDMRDMV EGDVRFSLPF GVGA

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL92212.1.
RefSeqYP_939002.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UHA4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1UHA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000055797; EBMYCP00000054021; EBMYCG00000055792.
GeneID4610851.
GenomeReviewsGene locus Mkms_3018 in contig CP000518_GR.
KEGGmkm:Mkms_3018.
PATRIC18105018. VBIMycSp70743_3542.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0016.
GeneTreeEBGT00050000016426.
HOGENOMHBG284353.
OMAFRASYFP.
ProtClustDBPRK00488.

Family and domain databases

HAMAPMF_00281. Phe_tRNA_synth_alpha1.
[Tree]
InterProIPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_synth_II_N.
IPR022911. Phe_tRNA_synth_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view]
KOK01889.
PfamPF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
SUPFAMSSF46589. tRNA_binding_arm. 1 hit.
TIGRFAMsTIGR00468. PheS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1UHA4_MYCSK
AccessionPrimary (citable) accession number: A1UHA4
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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