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A1UH95 (ARLY_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Mkms_3009
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Argininosuccinate lyase HAMAP MF_00006
PRO_1000000508

Sequences

Sequence LengthMass (Da)Tools
A1UH95 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: B0044F6D4805919A

FASTA47049,660
        10         20         30         40         50         60 
MSTNEGSLWG GRFADGPADA LAALSKSTHF DWVLAPYDIA ASKAHARVLF SAGLLTEDQR 

        70         80         90        100        110        120 
DGLLAGLDSL ASDVADGSFA PLVTDEDVHG ALERGLIDRV GAELGGRLRA GRSRNDQVAT 

       130        140        150        160        170        180 
LFRAWLRDAI RRVADGVLGV VSALATQAAA HPTAIMPGKT HLQSAQPVLL AHHLLAHAHP 

       190        200        210        220        230        240 
LLRDVDRLAD FDKRAAVSPY GAGALAGSSL GLDPDAIAAE LGFDSAADNS IDATAARDFA 

       250        260        270        280        290        300 
AEAAFVLAMI GVDLSRLAED IILWSTTEFG YVTLHDAWST GSSIMPQKKN PDIAELARGK 

       310        320        330        340        350        360 
SGRLIGNLTG LLATLKAQPL AYNRDLQEDK EPVFDSVAQL ELLLPAVAGL VSTLSFDVDR 

       370        380        390        400        410        420 
MAELAPLGYT LATDVAEWLV RRGVPFRVAH EAAGAAVRAA EARGVGLEDL EDAELTGIHP 

       430        440        450        460        470 
ELTGDVREVL TIEGSVNSRD ARGGTAPVQV AKQLNVVRDT ADRLRLRLRT

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL92203.1.
RefSeqYP_938993.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UH95.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1UH95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000054262; EBMYCP00000052486; EBMYCG00000054257.
GeneID4610842.
GenomeReviewsGene locus Mkms_3009 in contig CP000518_GR.
KEGGmkm:Mkms_3009.
PATRIC18105000. VBIMycSp70743_3533.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00050000016253.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycMSP189918:MKMS_3009-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_MYCSK
AccessionPrimary (citable) accession number: A1UH95
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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