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A1UGU7

- MASZ_MYCSK

UniProt

A1UGU7 - MASZ_MYCSK

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Protein

Malate synthase G

Gene

glcB

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei277 – 2771Acetyl-CoAUniRule annotation
Binding sitei314 – 3141Acetyl-CoAUniRule annotation
Active sitei342 – 3421Proton acceptorUniRule annotation
Binding sitei342 – 3421GlyoxylateUniRule annotation
Metal bindingi437 – 4371MagnesiumUniRule annotation
Binding sitei437 – 4371GlyoxylateUniRule annotation
Metal bindingi465 – 4651MagnesiumUniRule annotation
Binding sitei546 – 5461Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei636 – 6361Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMSP189918:GH4X-2878-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:Mkms_2861
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Malate synthase GPRO_1000056908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei622 – 6221Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi189918.Mkms_2861.

Structurei

3D structure databases

ProteinModelPortaliA1UGU7.
SMRiA1UGU7. Positions 5-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA bindingUniRule annotation
Regioni462 – 4654Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSTIMDFE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UGU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDRVTVGNL RVARALYDFI TDEALAGTDL DPDSFWSGVD KVVADLTPRN
60 70 80 90 100
QELLARRDDL QAQIDKWHRQ RAIGPHDADE YKQFLTEIGY LEPDPGDFTI
110 120 130 140 150
TTAGVDDEIT TTAGPQLVVP VLNARFALNA ANARWGSLYD ALYGTDVISE
160 170 180 190 200
EDGAEKGTSY NRVRGDKVIA YAREFLDGAA PLASGSYADA TGFRIEDGQV
210 220 230 240 250
QVELGDDQWV GLADPDQFVG YTGELGSPQW SILLRNNGLH IEILIDPDSP
260 270 280 290 300
VGSTDKAGVK DVVLESAVTT IMDFEDSVAA VDAEDKVLGY RNWLGLNRGD
310 320 330 340 350
LSEEVSKGDK TFTRVLNPDR TYTTPDGSGE LTLPGRSLLF VRNVGHLMTN
360 370 380 390 400
DAITDAEGNE VFEGIQDALF TGLIAMHGLK ESDANGPLRN SRTGSVYIVK
410 420 430 440 450
PKMHGPAEVA YTVDLFSRVE DVLGLPQNTL KVGIMDEERR TTLNLKACIK
460 470 480 490 500
AAADRVVFIN TGFLDRTGDE IHTSMEAGPM IRKGAMKSQP WIKAYEDQNV
510 520 530 540 550
DVGLATGFSG RAQIGKGMWA MTDLMADMVE QKIGQPKAGA TTAWVPSPTA
560 570 580 590 600
ATLHAMHYHQ VDVYAVHKEL EGKQRASLDD LLTIPLAKEL AWAPEEIREE
610 620 630 640 650
VDNNCQSILG YVVRWIDAGV GCSKVPDIHD IALMEDRATL RISSQLLANW
660 670 680 690 700
LRHGVITEED VKTSLRRMAA VVDEQNAKDP DFKPMATDPD SSIAFQAAQE
710 720 730
LILAGGTQPS GYTEPILHRR RREYKASVAG A
Length:731
Mass (Da):79,921
Last modified:February 6, 2007 - v1
Checksum:i05AB383646FED936
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL92055.1.
RefSeqiYP_938845.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL92055; ABL92055; Mkms_2861.
GeneIDi4611050.
KEGGimkm:Mkms_2861.
PATRICi18104696. VBIMycSp70743_3385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL92055.1 .
RefSeqi YP_938845.1. NC_008705.1.

3D structure databases

ProteinModelPortali A1UGU7.
SMRi A1UGU7. Positions 5-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189918.Mkms_2861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL92055 ; ABL92055 ; Mkms_2861 .
GeneIDi 4611050.
KEGGi mkm:Mkms_2861.
PATRICi 18104696. VBIMycSp70743_3385.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi STIMDFE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci MSP189918:GH4X-2878-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMS.

Entry informationi

Entry nameiMASZ_MYCSK
AccessioniPrimary (citable) accession number: A1UGU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3