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A1UGU7 (MASZ_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate synthase G
EC=2.3.3.9
Gene names
Name:glcB
Ordered Locus Names:Mkms_2861
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length731 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA. HAMAP-Rule MF_00641

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. HAMAP-Rule MF_00641

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the malate synthase family. GlcB subfamily.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: HAMAP

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmalate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 731731Malate synthase G HAMAP-Rule MF_00641
PRO_1000056908

Sites

Active site3421Proton acceptor By similarity
Active site6361Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
A1UGU7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 05AB383646FED936

FASTA73179,921
        10         20         30         40         50         60 
MTDRVTVGNL RVARALYDFI TDEALAGTDL DPDSFWSGVD KVVADLTPRN QELLARRDDL 

        70         80         90        100        110        120 
QAQIDKWHRQ RAIGPHDADE YKQFLTEIGY LEPDPGDFTI TTAGVDDEIT TTAGPQLVVP 

       130        140        150        160        170        180 
VLNARFALNA ANARWGSLYD ALYGTDVISE EDGAEKGTSY NRVRGDKVIA YAREFLDGAA 

       190        200        210        220        230        240 
PLASGSYADA TGFRIEDGQV QVELGDDQWV GLADPDQFVG YTGELGSPQW SILLRNNGLH 

       250        260        270        280        290        300 
IEILIDPDSP VGSTDKAGVK DVVLESAVTT IMDFEDSVAA VDAEDKVLGY RNWLGLNRGD 

       310        320        330        340        350        360 
LSEEVSKGDK TFTRVLNPDR TYTTPDGSGE LTLPGRSLLF VRNVGHLMTN DAITDAEGNE 

       370        380        390        400        410        420 
VFEGIQDALF TGLIAMHGLK ESDANGPLRN SRTGSVYIVK PKMHGPAEVA YTVDLFSRVE 

       430        440        450        460        470        480 
DVLGLPQNTL KVGIMDEERR TTLNLKACIK AAADRVVFIN TGFLDRTGDE IHTSMEAGPM 

       490        500        510        520        530        540 
IRKGAMKSQP WIKAYEDQNV DVGLATGFSG RAQIGKGMWA MTDLMADMVE QKIGQPKAGA 

       550        560        570        580        590        600 
TTAWVPSPTA ATLHAMHYHQ VDVYAVHKEL EGKQRASLDD LLTIPLAKEL AWAPEEIREE 

       610        620        630        640        650        660 
VDNNCQSILG YVVRWIDAGV GCSKVPDIHD IALMEDRATL RISSQLLANW LRHGVITEED 

       670        680        690        700        710        720 
VKTSLRRMAA VVDEQNAKDP DFKPMATDPD SSIAFQAAQE LILAGGTQPS GYTEPILHRR 

       730 
RREYKASVAG A

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL92055.1.
RefSeqYP_938845.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UGU7.
SMRA1UGU7. Positions 5-729.
ModBaseSearch...

Protein-protein interaction databases

STRING189918.Mkms_2861.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL92055; ABL92055; Mkms_2861.
GeneID4611050.
KEGGmkm:Mkms_2861.
PATRIC18104696. VBIMycSp70743_3385.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2225.
HOGENOMHOG000220740.
KOK01638.
OMAVVKPKMH.
ProtClustDBPRK02999.

Enzyme and pathway databases

BioCycMSP189918:GH4X-2918-MONOMER.
UniPathwayUPA00703; UER00720.

Family and domain databases

Gene3D2.170.170.11. 2 hits.
HAMAPMF_00641. Malate_synth_G.
InterProIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PANTHERPTHR21631:SF1. PTHR21631:SF1. 1 hit.
PfamPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMSSF51645. Malat_synth_like. 1 hit.
TIGRFAMsTIGR01345. malate_syn_G. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMASZ_MYCSK
AccessionPrimary (citable) accession number: A1UGU7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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