tpiA

Functionⁱ

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityⁱ

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayⁱ: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

Triosephosphate isomerase (tpiA)

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	100	ElectrophileUniRule annotation	1
Active siteⁱ	172	Proton acceptorUniRule annotation	1
Binding siteⁱ	178	Substrate; via amide nitrogenUniRule annotation	1
Binding siteⁱ	218	SubstrateUniRule annotation	1

GO - Molecular functionⁱ

triose-phosphate isomerase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-UniPathway
glycolytic process Source: UniProtKB-UniPathway
pentose-phosphate shunt Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00189. UPA00138.

UniPathwayⁱ

UPA00109; UER00189.
UPA00138.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation) Short name: TIMUniRule annotation Short name: TPIUniRule annotation Alternative name(s): Triose-phosphate isomeraseUniRule annotation
Gene namesⁱ	Name:tpiAUniRule annotation Ordered Locus Names:Mkms_2452
Organismⁱ	Mycobacterium sp. (strain KMS)
Taxonomic identifierⁱ	189918 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium
Proteomesⁱ	UP000000638 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00147

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000307506	1 – 261	Triosephosphate isomeraseAdd BLAST		261

Interactionⁱ

Subunit structureⁱ

Homodimer.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A1UFP1.
SMRⁱ	A1UFP1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	10 – 12	Substrate bindingUniRule annotation		3
Regionⁱ	239 – 240	Substrate bindingUniRule annotation		2

Sequence similaritiesⁱ

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000226414.
KEGG Orthology (KO) More...KOⁱ	K01803.
OMAⁱ	LCVGEGL.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02GL.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00311. TIM. 1 hit.
Gene3Dⁱ	3.20.20.70. 1 hit.
HAMAPⁱ	MF_00147_B. TIM_B. 1 hit.
InterProⁱ	View protein in InterPro IPR013785. Aldolase_TIM. IPR035990. TIM_sf. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS.
PANTHERⁱ	PTHR21139. PTHR21139. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00121. TIM. 1 hit.
SUPFAMⁱ	SSF51351. SSF51351. 1 hit.
TIGRFAMsⁱ	TIGR00419. tim. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A1UFP1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARKPLIAGN WKMNLNHFEA IALVQKIAFS LPDKYFDKVD VTVIPPFTDL 
        60         70         80         90        100
RSVQTLVDGD KLRLSYGAQD VSQHDSGAYT GEISGAFLAK LGCSFAVVGH 
       110        120        130        140        150
SERRTYHHED DALVAAKAAA AFRHGITPIV CIGEHLKVRE AGNHVEHNVE 
       160        170        180        190        200
QLRGSLAGLT SEQIGQAVIA YEPVWAIGTG RVAGAADAQE VCKAIRDELG 
       210        220        230        240        250
KLSSPQLAAG IRVLYGGSVN AKNVGEIVAQ EDVDGALVGG ASLDGEQFAT 
       260 
LSAIAAGGPL P

Length:261

Mass (Da):27,477

Last modified:February 6, 2007 - v1

Checksum:ⁱ47E56F1A4CCE4231

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000518 Genomic DNA. Translation: ABL91649.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011559803.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABL91649; ABL91649; Mkms_2452.
GeneIDⁱ	32422682.
KEGGⁱ	mkm:Mkms_2452.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A1UFP1	A3PZA3 Q1B9C0 A0A1A0U3Z4	Mycobacterium sp. (strain JLS) Mycobacterium sp. (strain MCS) Mycobacterium sp. 852013-50142_SCH4511227	261	UniRef100_A3PZA3	Cluster: Triosephosphate isomerase	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A1UFP1	A4TC25 A0A1X2BDI3 A0A0B2YSH5 A0A1E7YDY0 A0A1S1KK14 A0A1Q9WCS3 A0A101BEN8 UPI000426525A UPI0007E9B2FA UPI00082C8805 +91	Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)) Mycobacterium peregrinum Mycobacterium setense Mycobacterium sp. (ex Dasyatis americana) Mycobacterium sp. 24999 Mycobacterium sp. 27335 Mycobacterium sp. GA-2829 Mycobacterium sp. URHD0025 Mycobacterium fortuitum Mycobacterium houstonense And more	261	UniRef90_A4TC25	Cluster: Triosephosphate isomerase	102

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A1UFP1	Q6AF43 A0A1E2SLE2 U3PCU9 UPI0009DB844F A0A258HPL0 UPI00064821B6 A0A1Y6CKV8 Q4JVJ4 A0A1V3DQQ4 A0A1E9Q4E3 +721	Leifsonia xyli subsp. xyli (strain CTCB07) Leifsonia xyli subsp. xyli Leifsonia xyli subsp. cynodontis DSM 46306 Leifsonia xyli Micrococcales bacterium 32-70-13 Mesorhizobium sp. F7 Tistlia consotensis USBA 355 Corynebacterium jeikeium (strain K411) Corynebacterium jeikeium Corynebacterium sp. HMSC058E07 And more	259	UniRef50_Q6AF43	Cluster: Triosephosphate isomerase	732

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000518 Genomic DNA. Translation: ABL91649.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011559803.1. NC_008705.1.

3D structure databases

ProteinModelPortalⁱ	A1UFP1.
SMRⁱ	A1UFP1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABL91649; ABL91649; Mkms_2452.
GeneIDⁱ	32422682.
KEGGⁱ	mkm:Mkms_2452.

Phylogenomic databases

HOGENOMⁱ	HOG000226414.
KEGG Orthology (KO) More...KOⁱ	K01803.
OMAⁱ	LCVGEGL.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02GL.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00189. UPA00138.

UniPathwayⁱ

UPA00109; UER00189.
UPA00138.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00311. TIM. 1 hit.
Gene3Dⁱ	3.20.20.70. 1 hit.
HAMAPⁱ	MF_00147_B. TIM_B. 1 hit.
InterProⁱ	View protein in InterPro IPR013785. Aldolase_TIM. IPR035990. TIM_sf. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS.
PANTHERⁱ	PTHR21139. PTHR21139. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00121. TIM. 1 hit.
SUPFAMⁱ	SSF51351. SSF51351. 1 hit.
TIGRFAMsⁱ	TIGR00419. tim. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TPIS_MYCSK
Accessionⁱ	A1UFP1Primary (citable) accession number: A1UFP1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
	Last sequence update:	February 6, 2007
	Last modified:	March 28, 2018
	This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A1UFP1 (TPIS_MYCSK)

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Triosephosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ