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A1UFM8

- RISB_MYCSK

UniProt

A1UFM8 - RISB_MYCSK

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Protein
6,7-dimethyl-8-ribityllumazine synthase
Gene
ribH, Mkms_2438
Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin By similarity.UniRule annotation

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei27 – 2715-amino-6-(D-ribitylamino)uracil By similarity
Active sitei89 – 891Proton donor Reviewed prediction
Binding sitei114 – 11415-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei128 – 12811-deoxy-L-glycero-tetrulose 4-phosphate By similarity

GO - Molecular functioni

  1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciMSP189918:GH4X-2455-MONOMER.
UniPathwayiUPA00275; UER00404.

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthase (EC:2.5.1.78)
Short name:
DMRL synthase
Short name:
LS
Short name:
Lumazine synthase
Gene namesi
Name:ribH
Ordered Locus Names:Mkms_2438
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1601606,7-dimethyl-8-ribityllumazine synthaseUniRule annotation
PRO_1000040456Add
BLAST

Interactioni

Subunit structurei

Homopentamer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi189918.Mkms_2438.

Structurei

3D structure databases

ProteinModelPortaliA1UFM8.
SMRiA1UFM8. Positions 10-160.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6135-amino-6-(D-ribitylamino)uracil binding By similarity
Regioni81 – 8335-amino-6-(D-ribitylamino)uracil binding By similarity
Regioni86 – 8721-deoxy-L-glycero-tetrulose 4-phosphate binding By similarity

Sequence similaritiesi

Belongs to the DMRL synthase family.

Phylogenomic databases

eggNOGiCOG0054.
HOGENOMiHOG000229253.
KOiK00794.
OMAiHDEISAG.
OrthoDBiEOG6RC3WC.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
HAMAPiMF_00178. Lumazine_synth.
InterProiIPR002180. DMRL_synthase.
[Graphical view]
PANTHERiPTHR21058. PTHR21058. 1 hit.
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UFM8-1 [UniParc]FASTAAdd to Basket

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MSGGAGVPDL PQIDASGMKV GIVASTWHST ICDALLDGAL KVTESANVSE    50
PTVVRVLGAI EIPVVAQALA ADHEAVIALG VVIRGQTPHF DYVCDAVTQG 100
LTRVSLDAST PVANGVLTTN TEEQALDRAG LPGSAEDKGA QAAAAALSTA 150
LTLQGLRGRS 160
Length:160
Mass (Da):16,110
Last modified:February 6, 2007 - v1
Checksum:i9E1B9A2F4015006A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL91636.1.
RefSeqiYP_938426.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL91636; ABL91636; Mkms_2438.
GeneIDi4613261.
KEGGimkm:Mkms_2438.
PATRICi18103821. VBIMycSp70743_2948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL91636.1 .
RefSeqi YP_938426.1. NC_008705.1.

3D structure databases

ProteinModelPortali A1UFM8.
SMRi A1UFM8. Positions 10-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189918.Mkms_2438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL91636 ; ABL91636 ; Mkms_2438 .
GeneIDi 4613261.
KEGGi mkm:Mkms_2438.
PATRICi 18103821. VBIMycSp70743_2948.

Phylogenomic databases

eggNOGi COG0054.
HOGENOMi HOG000229253.
KOi K00794.
OMAi HDEISAG.
OrthoDBi EOG6RC3WC.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00404 .
BioCyci MSP189918:GH4X-2455-MONOMER.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
HAMAPi MF_00178. Lumazine_synth.
InterProi IPR002180. DMRL_synthase.
[Graphical view ]
PANTHERi PTHR21058. PTHR21058. 1 hit.
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMS.

Entry informationi

Entry nameiRISB_MYCSK
AccessioniPrimary (citable) accession number: A1UFM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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