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A1UFM8

- RISB_MYCSK

UniProt

A1UFM8 - RISB_MYCSK

Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene

ribH

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.UniRule annotation

    Catalytic activityi

    1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei27 – 2715-amino-6-(D-ribitylamino)uracilUniRule annotation
    Active sitei89 – 891Proton donorUniRule annotation
    Binding sitei114 – 11415-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei128 – 12811-deoxy-L-glycero-tetrulose 4-phosphateUniRule annotation

    GO - Molecular functioni

    1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Enzyme and pathway databases

    BioCyciMSP189918:GH4X-2455-MONOMER.
    UniPathwayiUPA00275; UER00404.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6,7-dimethyl-8-ribityllumazine synthaseUniRule annotation (EC:2.5.1.78UniRule annotation)
    Short name:
    DMRL synthaseUniRule annotation
    Short name:
    LSUniRule annotation
    Short name:
    Lumazine synthaseUniRule annotation
    Gene namesi
    Name:ribHUniRule annotation
    Ordered Locus Names:Mkms_2438
    OrganismiMycobacterium sp. (strain KMS)
    Taxonomic identifieri189918 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000638: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. riboflavin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1601606,7-dimethyl-8-ribityllumazine synthasePRO_1000040456Add
    BLAST

    Interactioni

    Subunit structurei

    Homopentamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi189918.Mkms_2438.

    Structurei

    3D structure databases

    ProteinModelPortaliA1UFM8.
    SMRiA1UFM8. Positions 10-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 6135-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
    Regioni81 – 8335-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
    Regioni86 – 8721-deoxy-L-glycero-tetrulose 4-phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DMRL synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0054.
    HOGENOMiHOG000229253.
    KOiK00794.
    OMAiHDEISAG.
    OrthoDBiEOG6RC3WC.

    Family and domain databases

    Gene3Di3.40.50.960. 1 hit.
    HAMAPiMF_00178. Lumazine_synth.
    InterProiIPR002180. DMRL_synthase.
    [Graphical view]
    PANTHERiPTHR21058. PTHR21058. 1 hit.
    PfamiPF00885. DMRL_synthase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52121. SSF52121. 1 hit.
    TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1UFM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGGAGVPDL PQIDASGMKV GIVASTWHST ICDALLDGAL KVTESANVSE    50
    PTVVRVLGAI EIPVVAQALA ADHEAVIALG VVIRGQTPHF DYVCDAVTQG 100
    LTRVSLDAST PVANGVLTTN TEEQALDRAG LPGSAEDKGA QAAAAALSTA 150
    LTLQGLRGRS 160
    Length:160
    Mass (Da):16,110
    Last modified:February 6, 2007 - v1
    Checksum:i9E1B9A2F4015006A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000518 Genomic DNA. Translation: ABL91636.1.
    RefSeqiYP_938426.1. NC_008705.1.

    Genome annotation databases

    EnsemblBacteriaiABL91636; ABL91636; Mkms_2438.
    GeneIDi4613261.
    KEGGimkm:Mkms_2438.
    PATRICi18103821. VBIMycSp70743_2948.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000518 Genomic DNA. Translation: ABL91636.1 .
    RefSeqi YP_938426.1. NC_008705.1.

    3D structure databases

    ProteinModelPortali A1UFM8.
    SMRi A1UFM8. Positions 10-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 189918.Mkms_2438.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL91636 ; ABL91636 ; Mkms_2438 .
    GeneIDi 4613261.
    KEGGi mkm:Mkms_2438.
    PATRICi 18103821. VBIMycSp70743_2948.

    Phylogenomic databases

    eggNOGi COG0054.
    HOGENOMi HOG000229253.
    KOi K00794.
    OMAi HDEISAG.
    OrthoDBi EOG6RC3WC.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00404 .
    BioCyci MSP189918:GH4X-2455-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.960. 1 hit.
    HAMAPi MF_00178. Lumazine_synth.
    InterProi IPR002180. DMRL_synthase.
    [Graphical view ]
    PANTHERi PTHR21058. PTHR21058. 1 hit.
    Pfami PF00885. DMRL_synthase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52121. SSF52121. 1 hit.
    TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KMS.

    Entry informationi

    Entry nameiRISB_MYCSK
    AccessioniPrimary (citable) accession number: A1UFM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3