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A1UFM8

- RISB_MYCSK

UniProt

A1UFM8 - RISB_MYCSK

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Protein

6,7-dimethyl-8-ribityllumazine synthase

Gene

ribH

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.UniRule annotation

Catalytic activityi

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei27 – 2715-amino-6-(D-ribitylamino)uracilUniRule annotation
Active sitei89 – 891Proton donorUniRule annotation
Binding sitei114 – 11415-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei128 – 12811-deoxy-L-glycero-tetrulose 4-phosphateUniRule annotation

GO - Molecular functioni

  1. 6,7-dimethyl-8-ribityllumazine synthase activity Source: UniProtKB-HAMAP
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Enzyme and pathway databases

BioCyciMSP189918:GH4X-2455-MONOMER.
UniPathwayiUPA00275; UER00404.

Names & Taxonomyi

Protein namesi
Recommended name:
6,7-dimethyl-8-ribityllumazine synthaseUniRule annotation (EC:2.5.1.78UniRule annotation)
Short name:
DMRL synthaseUniRule annotation
Short name:
LSUniRule annotation
Short name:
Lumazine synthaseUniRule annotation
Gene namesi
Name:ribHUniRule annotation
Ordered Locus Names:Mkms_2438
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1601606,7-dimethyl-8-ribityllumazine synthasePRO_1000040456Add
BLAST

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Protein-protein interaction databases

STRINGi189918.Mkms_2438.

Structurei

3D structure databases

ProteinModelPortaliA1UFM8.
SMRiA1UFM8. Positions 10-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 6135-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
Regioni81 – 8335-amino-6-(D-ribitylamino)uracil bindingUniRule annotation
Regioni86 – 8721-deoxy-L-glycero-tetrulose 4-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DMRL synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0054.
HOGENOMiHOG000229253.
KOiK00794.
OMAiHDEISAG.
OrthoDBiEOG6RC3WC.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
HAMAPiMF_00178. Lumazine_synth.
InterProiIPR002180. DMRL_synthase.
[Graphical view]
PANTHERiPTHR21058. PTHR21058. 1 hit.
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR00114. lumazine-synth. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UFM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGGAGVPDL PQIDASGMKV GIVASTWHST ICDALLDGAL KVTESANVSE
60 70 80 90 100
PTVVRVLGAI EIPVVAQALA ADHEAVIALG VVIRGQTPHF DYVCDAVTQG
110 120 130 140 150
LTRVSLDAST PVANGVLTTN TEEQALDRAG LPGSAEDKGA QAAAAALSTA
160
LTLQGLRGRS
Length:160
Mass (Da):16,110
Last modified:February 6, 2007 - v1
Checksum:i9E1B9A2F4015006A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL91636.1.
RefSeqiYP_938426.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL91636; ABL91636; Mkms_2438.
GeneIDi4613261.
KEGGimkm:Mkms_2438.
PATRICi18103821. VBIMycSp70743_2948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL91636.1 .
RefSeqi YP_938426.1. NC_008705.1.

3D structure databases

ProteinModelPortali A1UFM8.
SMRi A1UFM8. Positions 10-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189918.Mkms_2438.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL91636 ; ABL91636 ; Mkms_2438 .
GeneIDi 4613261.
KEGGi mkm:Mkms_2438.
PATRICi 18103821. VBIMycSp70743_2948.

Phylogenomic databases

eggNOGi COG0054.
HOGENOMi HOG000229253.
KOi K00794.
OMAi HDEISAG.
OrthoDBi EOG6RC3WC.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00404 .
BioCyci MSP189918:GH4X-2455-MONOMER.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
HAMAPi MF_00178. Lumazine_synth.
InterProi IPR002180. DMRL_synthase.
[Graphical view ]
PANTHERi PTHR21058. PTHR21058. 1 hit.
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR00114. lumazine-synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMS.

Entry informationi

Entry nameiRISB_MYCSK
AccessioniPrimary (citable) accession number: A1UFM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3