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A1UEQ5 (MQO_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene names
Name:mqo
Ordered Locus Names:Mkms_2115
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length516 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212

Cofactor

FAD By similarity. HAMAP MF_00212

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212

Sequence similarities

Belongs to the MQO family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmalate dehydrogenase (menaquinone) activity

Inferred from electronic annotation. Source: EC

malate dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 516516Probable malate:quinone oxidoreductase HAMAP MF_00212
PRO_0000325503

Sequences

Sequence LengthMass (Da)Tools
A1UEQ5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: EEC9685C404ACFEF

FASTA51656,003
        10         20         30         40         50         60 
MSDAQVAKTD VVLVGAGIMS ATLSALIKLL EPNWSITLIE RLDGAAAESS DPWNNAGTGH 

        70         80         90        100        110        120 
SALCELNYTP EGPGGSIDIT KAVHVNEQFQ VSRQFWTYAV ENGVLPDVRN FINPIPHVSF 

       130        140        150        160        170        180 
VSGARNVEYL RARYDALVPN PLFATMEYID DRDEFARRLP FMADKRDFRE PVALNWSQDG 

       190        200        210        220        230        240 
TDIDFGSLSR QLIGYTAQRG MTTLFGHEVR DLDKQSDGSW SVKVVNRRTG AKRKLNAKFV 

       250        260        270        280        290        300 
FVGAGGGALP LLQKAGIEEA KGFGGFPVGG QWLRTGNPEL TARHQAKVYG MPPLGAPPMS 

       310        320        330        340        350        360 
VPHLDTRVIN GKSWLLFGPF AGWSPKFLKQ GKVTDLPFSV KPNNLASMLG VGLTEMGLLK 

       370        380        390        400        410        420 
YLIGQLLLSE ADRVETLRNF APSARDSDWE LDIAGQRVQV IRRKGKGGVL EFGTTVLAAK 

       430        440        450        460        470        480 
DGSIAGLLGA SPGASTAVPA MLDVMERCFG DRYTAWLPKL KEIVPSLGTK LSDEPKLFQE 

       490        500        510 
IWAHGTKVLK LDHPAAGLPV AGTDTEHREP ATTVTA

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL91313.1.
RefSeqYP_938103.1. NC_008705.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1UEQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000056169; EBMYCP00000054393; EBMYCG00000056164.
GeneID4613474.
GenomeReviewsGene locus Mkms_2115 in contig CP000518_GR.
KEGGmkm:Mkms_2115.
PATRIC18103151. VBIMycSp70743_2617.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0579.
GeneTreeEBGT00050000015585.
HOGENOMHBG289663.
OMAKKWVPLM.
ProtClustDBPRK05257.

Enzyme and pathway databases

BioCycMSP189918:MKMS_2115-MONOMER.

Family and domain databases

HAMAPMF_00212. MQO.
[Tree]
InterProIPR006231. Malate_quinone_OxRdtase.
[Graphical view]
KOK00116.
PANTHERPTHR13847:SF14. PTHR13847:SF14. 1 hit.
PfamPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsTIGR01320. Mal_quin_oxido. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMQO_MYCSK
AccessionPrimary (citable) accession number: A1UEQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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