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Protein

Ribonuclease HII

Gene

rnhB

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36Divalent metal cationUniRule annotation1
Metal bindingi37Divalent metal cationUniRule annotation1
Metal bindingi130Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:Mkms_2018
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000638 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000311661 – 239Ribonuclease HIIAdd BLAST239

Structurei

3D structure databases

ProteinModelPortaliA1UEF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000100288.
KOiK03470.
OMAiGFASHKG.
OrthoDBiPOG091H011N.

Family and domain databases

CDDicd07182. RNase_HII_bacteria_HII_like. 1 hit.
Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B. 1 hit.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UEF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASWPPRTV IRKASGLRTL ESALYRNGLG PVAGVDEVGR GACAGPLVVA
60 70 80 90 100
ACVLGPNRLE SLAALDDSKK LGEKERERLF PVIRRYALAY HVVFIPSEEV
110 120 130 140 150
DRRGVHVANI EGMRRAVAGL SVRPGYVLSD GFRVPGLPMP SLPVVGGDAA
160 170 180 190 200
AACIAAASVL AKVSRDRLMV AMEREHPGYG FAEHKGYSTP AHTAALAELG
210 220 230
PCAQHRYSFI NVRRLVTAGT PQISGGLTDA EPGQCCELG
Length:239
Mass (Da):25,290
Last modified:February 6, 2007 - v1
Checksum:iB4D1F7FB8FD21694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL91217.1.
RefSeqiWP_011559371.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL91217; ABL91217; Mkms_2018.
KEGGimkm:Mkms_2018.
PATRICi18102954. VBIMycSp70743_2519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL91217.1.
RefSeqiWP_011559371.1. NC_008705.1.

3D structure databases

ProteinModelPortaliA1UEF9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL91217; ABL91217; Mkms_2018.
KEGGimkm:Mkms_2018.
PATRICi18102954. VBIMycSp70743_2519.

Phylogenomic databases

HOGENOMiHOG000100288.
KOiK03470.
OMAiGFASHKG.
OrthoDBiPOG091H011N.

Family and domain databases

CDDicd07182. RNase_HII_bacteria_HII_like. 1 hit.
Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B. 1 hit.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNH2_MYCSK
AccessioniPrimary (citable) accession number: A1UEF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.