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A1UDY9 (DNLI_MYCSK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:Mkms_1846
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000365229

Sites

Active site2151N6-AMP-lysine intermediate By similarity
Binding site2131ATP By similarity
Binding site2201ATP By similarity
Binding site2351ATP By similarity
Binding site2641ATP By similarity
Binding site3001ATP By similarity
Binding site3721ATP By similarity
Binding site3781ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1UDY9 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: AC030FF721DFE324

FASTA52054,705
        10         20         30         40         50         60 
MLLVDVATAS VDVGAMSSRL AKTARIADLL SRAGTEQDAR LVAVTVAWLS GELPQRQIGV 

        70         80         90        100        110        120 
GWAALRSLPA PAAAPTLTVT AVDAVFSEIG AVAGKGSQAR RAGLIAELFA AATDVEQTFL 

       130        140        150        160        170        180 
RRLLTGELRQ GALIGVMADA VAKAADVPAA RVRRAAMLAG DLPAVAAAVL AGGDAALARF 

       190        200        210        220        230        240 
TLQVGRPVGP MLAQTATGVA DALDRLGGTA VFEAKLDGAR VQIHRRGSDV SVYTRSLDDV 

       250        260        270        280        290        300 
TARLPEVVEA ALALPVTDLI ADAEAIALRP DGRPHRFQVT ASRFGRAAAR ATQPLSVFMF 

       310        320        330        340        350        360 
DLLHVDGADL LDQPTSDRVR VLDDLVPAAH RVDRLVTDDG AAAQRFLEAT LAAGHEGVMA 

       370        380        390        400        410        420 
KSPNAPYEAG RRGAGWLKVK PVHTLDLVVL AVEWGSGRRT GKLSNIHLGA RDPATGGFVM 

       430        440        450        460        470        480 
LGKTFKGMTD AMLDWQTARF LELADPAAQP ATSGRDPTDG HTVKVRPEQV VEIAFDGVQG 

       490        500        510        520 
STRYPGGMAL RFARVLRYRD DKSPAEADTV DTVRAFYEHG 

« Hide

References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000518 Genomic DNA. Translation: ABL91047.1.
RefSeqYP_937837.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UDY9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING189918.Mkms_1846.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL91047; ABL91047; Mkms_1846.
GeneID4613773.
KEGGmkm:Mkms_1846.
PATRIC18102598. VBIMycSp70743_2343.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAGRPRPFQ.
OrthoDBEOG6Q8HXT.
ProtClustDBPRK03180.

Enzyme and pathway databases

BioCycMSP189918:GH4X-1857-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_MYCSK
AccessionPrimary (citable) accession number: A1UDY9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families