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A1UDY9

- DNLI_MYCSK

UniProt

A1UDY9 - DNLI_MYCSK

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Protein

Probable DNA ligase

Gene

lig

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATPUniRule annotation
Active sitei215 – 2151N6-AMP-lysine intermediateUniRule annotation
Binding sitei220 – 2201ATPUniRule annotation
Binding sitei235 – 2351ATPUniRule annotation
Binding sitei264 – 2641ATPUniRule annotation
Binding sitei300 – 3001ATPUniRule annotation
Binding sitei372 – 3721ATPUniRule annotation
Binding sitei378 – 3781ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP189918:GH4X-1857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mkms_1846
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Probable DNA ligasePRO_0000365229Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi189918.Mkms_1846.

Structurei

3D structure databases

ProteinModelPortaliA1UDY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiKTENNIS.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1UDY9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLVDVATAS VDVGAMSSRL AKTARIADLL SRAGTEQDAR LVAVTVAWLS
60 70 80 90 100
GELPQRQIGV GWAALRSLPA PAAAPTLTVT AVDAVFSEIG AVAGKGSQAR
110 120 130 140 150
RAGLIAELFA AATDVEQTFL RRLLTGELRQ GALIGVMADA VAKAADVPAA
160 170 180 190 200
RVRRAAMLAG DLPAVAAAVL AGGDAALARF TLQVGRPVGP MLAQTATGVA
210 220 230 240 250
DALDRLGGTA VFEAKLDGAR VQIHRRGSDV SVYTRSLDDV TARLPEVVEA
260 270 280 290 300
ALALPVTDLI ADAEAIALRP DGRPHRFQVT ASRFGRAAAR ATQPLSVFMF
310 320 330 340 350
DLLHVDGADL LDQPTSDRVR VLDDLVPAAH RVDRLVTDDG AAAQRFLEAT
360 370 380 390 400
LAAGHEGVMA KSPNAPYEAG RRGAGWLKVK PVHTLDLVVL AVEWGSGRRT
410 420 430 440 450
GKLSNIHLGA RDPATGGFVM LGKTFKGMTD AMLDWQTARF LELADPAAQP
460 470 480 490 500
ATSGRDPTDG HTVKVRPEQV VEIAFDGVQG STRYPGGMAL RFARVLRYRD
510 520
DKSPAEADTV DTVRAFYEHG
Length:520
Mass (Da):54,705
Last modified:February 6, 2007 - v1
Checksum:iAC030FF721DFE324
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL91047.1.
RefSeqiYP_937837.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL91047; ABL91047; Mkms_1846.
GeneIDi4613773.
KEGGimkm:Mkms_1846.
PATRICi18102598. VBIMycSp70743_2343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000518 Genomic DNA. Translation: ABL91047.1 .
RefSeqi YP_937837.1. NC_008705.1.

3D structure databases

ProteinModelPortali A1UDY9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 189918.Mkms_1846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL91047 ; ABL91047 ; Mkms_1846 .
GeneIDi 4613773.
KEGGi mkm:Mkms_1846.
PATRICi 18102598. VBIMycSp70743_2343.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi KTENNIS.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci MSP189918:GH4X-1857-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMS.

Entry informationi

Entry nameiDNLI_MYCSK
AccessioniPrimary (citable) accession number: A1UDY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3