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A1UDY9

- DNLI_MYCSK

UniProt

A1UDY9 - DNLI_MYCSK

Protein

Probable DNA ligase

Gene

lig

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei213 – 2131ATPUniRule annotation
    Active sitei215 – 2151N6-AMP-lysine intermediateUniRule annotation
    Binding sitei220 – 2201ATPUniRule annotation
    Binding sitei235 – 2351ATPUniRule annotation
    Binding sitei264 – 2641ATPUniRule annotation
    Binding sitei300 – 3001ATPUniRule annotation
    Binding sitei372 – 3721ATPUniRule annotation
    Binding sitei378 – 3781ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSP189918:GH4X-1857-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mkms_1846
    OrganismiMycobacterium sp. (strain KMS)
    Taxonomic identifieri189918 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000638: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Probable DNA ligasePRO_0000365229Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi189918.Mkms_1846.

    Structurei

    3D structure databases

    ProteinModelPortaliA1UDY9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiKTENNIS.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1UDY9-1 [UniParc]FASTAAdd to Basket

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    MLLVDVATAS VDVGAMSSRL AKTARIADLL SRAGTEQDAR LVAVTVAWLS    50
    GELPQRQIGV GWAALRSLPA PAAAPTLTVT AVDAVFSEIG AVAGKGSQAR 100
    RAGLIAELFA AATDVEQTFL RRLLTGELRQ GALIGVMADA VAKAADVPAA 150
    RVRRAAMLAG DLPAVAAAVL AGGDAALARF TLQVGRPVGP MLAQTATGVA 200
    DALDRLGGTA VFEAKLDGAR VQIHRRGSDV SVYTRSLDDV TARLPEVVEA 250
    ALALPVTDLI ADAEAIALRP DGRPHRFQVT ASRFGRAAAR ATQPLSVFMF 300
    DLLHVDGADL LDQPTSDRVR VLDDLVPAAH RVDRLVTDDG AAAQRFLEAT 350
    LAAGHEGVMA KSPNAPYEAG RRGAGWLKVK PVHTLDLVVL AVEWGSGRRT 400
    GKLSNIHLGA RDPATGGFVM LGKTFKGMTD AMLDWQTARF LELADPAAQP 450
    ATSGRDPTDG HTVKVRPEQV VEIAFDGVQG STRYPGGMAL RFARVLRYRD 500
    DKSPAEADTV DTVRAFYEHG 520
    Length:520
    Mass (Da):54,705
    Last modified:February 6, 2007 - v1
    Checksum:iAC030FF721DFE324
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000518 Genomic DNA. Translation: ABL91047.1.
    RefSeqiYP_937837.1. NC_008705.1.

    Genome annotation databases

    EnsemblBacteriaiABL91047; ABL91047; Mkms_1846.
    GeneIDi4613773.
    KEGGimkm:Mkms_1846.
    PATRICi18102598. VBIMycSp70743_2343.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000518 Genomic DNA. Translation: ABL91047.1 .
    RefSeqi YP_937837.1. NC_008705.1.

    3D structure databases

    ProteinModelPortali A1UDY9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 189918.Mkms_1846.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL91047 ; ABL91047 ; Mkms_1846 .
    GeneIDi 4613773.
    KEGGi mkm:Mkms_1846.
    PATRICi 18102598. VBIMycSp70743_2343.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi KTENNIS.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci MSP189918:GH4X-1857-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KMS.

    Entry informationi

    Entry nameiDNLI_MYCSK
    AccessioniPrimary (citable) accession number: A1UDY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3