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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei213SubstrateUniRule annotation1
Binding sitei243SubstrateUniRule annotation1
Binding sitei247SubstrateUniRule annotation1
Binding sitei248NADUniRule annotation1
Binding sitei300NADUniRule annotation1
Binding sitei335NADUniRule annotation1
Binding sitei403NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi214 – 216NADUniRule annotation3
Nucleotide bindingi277 – 282NADUniRule annotation6
Nucleotide bindingi356 – 358NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Mkms_1354
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000638 Componenti: Chromosome

Subcellular locationi

A1UCK8:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000247341 – 489AdenosylhomocysteinaseAdd BLAST489

Structurei

3D structure databases

ProteinModelPortaliA1UCK8.
SMRiA1UCK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UCK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTEQRLTV ESRNGIDYKV ADLSLAEFGR KEIRLAEHEM PGLMALRREY
60 70 80 90 100
AEVAPLKGAR ISGSLHMTVQ TAVLIETLVS LGAEVRWASC NIFSTQDHAA
110 120 130 140 150
AAVVVGPHGT PEEPKGTPVF AWKGETLEEY WWAAEQMLTW PGEPANMILD
160 170 180 190 200
DGGDATMLVL RGAQFEKAGV VPPAEDDDSA EYKVFLNLLR ERFETDKTKW
210 220 230 240 250
TKIAESVKGV TEETTTGVLR LYQFEAAGEL PFPAINVNDS VTKSKFDNKY
260 270 280 290 300
GTRHSLIDGI NRGTDVLIGG KKVLICGYGD VGKGCAESLA GQGARVQVTE
310 320 330 340 350
IDPINALQAL MDGFDVVTVE QAIGSADIVI TSTGNKDIIT LDHMKAMKDK
360 370 380 390 400
AILGNIGHFD NEIDMAALER SGATRINIKP QVDEWTFDDG HSIVLLSEGR
410 420 430 440 450
LLNLGNATGH PSFVMSNSFS NQVIAQIELW TKNDEYDNAV YRLAKHLDEK
460 470 480
VARIHVEALG GTLTKLTKEQ AEYINVDVEG PYKPEHYRY
Length:489
Mass (Da):53,727
Last modified:February 6, 2007 - v1
Checksum:i414490694169EF95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL90566.1.
RefSeqiWP_011558747.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL90566; ABL90566; Mkms_1354.
GeneIDi32418954.
KEGGimkm:Mkms_1354.

Similar proteinsi

Entry informationi

Entry nameiSAHH_MYCSK
AccessioniPrimary (citable) accession number: A1UCK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families