A1UC54 (A1UC54_MYCSK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	Mkms_1200

Organism

Mycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]

Taxonomic identifier

189918 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1099 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1UC54 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: F6A02F081E4CB4E1	FASTA	1,099	119,268
	10 20 30 40 50 60 MGFSNGPTWP EIERVLNGKP RRAGESLREP PGDGGDSPAW SRKRGAYQAP QLPRSGGAVP 70 80 90 100 110 120 YAELHAHSAY SFLDGAGTPE ELVEEAARLD LRAIALTDHD GLYGVVRFAE AARELDMRTV 130 140 150 160 170 180 FGAELSLGMG ARSARNEVPD PPGPHLLVLA RGPEGYRRLS REIAKAHLAG GEKGKPRYDY 190 200 210 220 230 240 DTLTEAAGGH WHILTGCRKG HVRQALSEGG PAAAEKALAD LVDRFGRDRV SVELTHHGHP 250 260 270 280 290 300 LDDERNAALA ELAPRFGLTV VATTAAHFAE PSRGRLAMAM GAIRARHSID EAAGYLAPLG 310 320 330 340 350 360 GSHLRSGEEM ARLFAHCPQV VTAAADLGEQ CAFGLALIAP KLPPFDVPAG HTEDSWLRHL 370 380 390 400 410 420 VMLGARNRYG PPERAPQAYA QIEHELRVIE KLSFPGYFLV VHDITRFCKE NGILAQGRGS 430 440 450 460 470 480 AANSAVCYAL GVTNVDPVAN ELLFERFLSP ARDGPPDIDI DIESDLREQA IQYVYDRYGR 490 500 510 520 530 540 DYAAQVANVI TYRGRSAIRD MARALGFSQG QQDAWSKQLS KWNGLADSPD IEGIPEPVVD 550 560 570 580 590 600 LALQISNLPR HMGIHSGGMV ICDRPIADVC PVEWARMANR SVLQWDKDDC AAIGLVKFDM 610 620 630 640 650 660 LGLGMLSALH YCIDLVREHK GLDVDLAKLD LSEPAVYEML QRADSVGVFQ VESRAQMATL 670 680 690 700 710 720 PRLKPRVFYD LVVEVALIRP GPIQGGSVHP YIKRRNGEEP VTYDHPSMAN ALRKTLGVPL 730 740 750 760 770 780 FQEQLMQLAV DCAGFTAAEA DQLRRAMGSK RSTEKMRRLR GRFYDGMRQR HGITGEVADR 790 800 810 820 830 840 IYDKLEAFAN FGFPESHSLS FASLVFYSSW FKLHHPAAFC AALLRAQPMG FYSPQSLVAD 850 860 870 880 890 900 ARRHGVTVHG PDVNASLAYA TLESAGTEVR LGLGAVRHIG DDLAERIVEE RKANGPFESL 910 920 930 940 950 960 LDLTGRVQLS VPQTEALATA GALGCFGVTR REGLWAAGAA AAERPDRLPG VGSAGQVPSL 970 980 990 1000 1010 1020 PGMSKLELAA ADVWATGVSP DSYPTQFLRE NLDAMGVVPA GRLLDVPDGT RVLVAGAVTH 1030 1040 1050 1060 1070 1080 RQRPATAQGV TFLNLEDETG MVNVVCSPQL WSRQRRLAQT APAMVIRGIV QNATGAVTVV 1090 ADKLGKLDMR VGSKSRDFR

References

[1]

"Complete sequence of chromosome of Mycobacterium sp. KMS." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KMS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000518 Genomic DNA. Translation: ABL90412.1.
RefSeq	YP_937202.1. NC_008705.1.
3D structure databases
ProteinModelPortal	A1UC54.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UC54.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000057586; EBMYCP00000055810; EBMYCG00000057581.
GeneID	4614396.
GenomeReviews	Gene locus Mkms_1200 in contig CP000518_GR.
KEGG	mkm:Mkms_1200.
PATRIC	18101347. VBIMycSp70743_1720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
GeneTree	EBGT00050000016568.
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1UC54_MYCSK

Accession

Primary (citable) accession number: A1UC54

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)