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Protein

Alanine racemase

Gene

Mkms_1163

Organism
Mycobacterium sp. (strain KMS)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Mkms_1163)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei42Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei140SubstrateUniRule annotation1
Active sitei271Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei319Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Mkms_1163Imported
OrganismiMycobacterium sp. (strain KMS)Imported
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000638 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliA1UC18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 379Ala_racemase_CInterPro annotationAdd BLAST130

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit

Sequencei

Sequence statusi: Complete.

A1UC18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSETTVTP TAQVVVDLDA ISHNVALLRD RAGSAQVMPV LKADGYGHGA
60 70 80 90 100
TEVAKVVLDA GVTELGVATV GEALALRADG ITAPVLAWLH GPGTDFAPAV
110 120 130 140 150
QADIQLAVSS VRQLGEILDA VHRTGMTATL TVKADTGLSR NGVSPAEYPA
160 170 180 190 200
LLQRLAKAQA EDAVRVRGIM SHLACGDEPD NPTNDRQAQR LTDMRRQAAD
210 220 230 240 250
AGVTFEVAHL CNSPAAMTRP DLAFDMVRPG IAVYGQTPIP ALGDMGLRPA
260 270 280 290 300
MTLRCPVAQT RSIKAGDGVS YGHTWIAQRD TTVALLPIGY ADGVYRSLSG
310 320 330 340 350
RLQVLINGRL RPGVGRICMD QFVVDLGPGP VDVSDGDEAI LFGPGTRGEH
360 370 380
TAQDWAEIIG TINYEIVTSP RGRVVRTYRR ESR
Length:383
Mass (Da):40,596
Last modified:February 6, 2007 - v1
Checksum:i15FE4CBBB7D4C283
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA Translation: ABL90376.1
RefSeqiWP_011558558.1, NC_008705.1

Genome annotation databases

EnsemblBacteriaiABL90376; ABL90376; Mkms_1163
GeneIDi32422784
KEGGimkm:Mkms_1163

Similar proteinsi

Entry informationi

Entry nameiA1UC18_MYCSK
AccessioniPrimary (citable) accession number: A1UC18
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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