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A1UC18

- A1UC18_MYCSK

UniProt

A1UC18 - A1UC18_MYCSK

Protein

Alanine racemase

Gene

Mkms_1163

Organism
Mycobacterium sp. (strain KMS)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei42 – 421Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei140 – 1401SubstrateUniRule annotation
    Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMSP189918:GH4X-1171-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Mkms_1163Imported
    OrganismiMycobacterium sp. (strain KMS)Imported
    Taxonomic identifieri189918 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000638: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei42 – 421N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi189918.Mkms_1163.

    Structurei

    3D structure databases

    ProteinModelPortaliA1UC18.
    SMRiA1UC18. Positions 12-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiGHTWTAQ.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1UC18-1 [UniParc]FASTAAdd to Basket

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    MQTSETTVTP TAQVVVDLDA ISHNVALLRD RAGSAQVMPV LKADGYGHGA    50
    TEVAKVVLDA GVTELGVATV GEALALRADG ITAPVLAWLH GPGTDFAPAV 100
    QADIQLAVSS VRQLGEILDA VHRTGMTATL TVKADTGLSR NGVSPAEYPA 150
    LLQRLAKAQA EDAVRVRGIM SHLACGDEPD NPTNDRQAQR LTDMRRQAAD 200
    AGVTFEVAHL CNSPAAMTRP DLAFDMVRPG IAVYGQTPIP ALGDMGLRPA 250
    MTLRCPVAQT RSIKAGDGVS YGHTWIAQRD TTVALLPIGY ADGVYRSLSG 300
    RLQVLINGRL RPGVGRICMD QFVVDLGPGP VDVSDGDEAI LFGPGTRGEH 350
    TAQDWAEIIG TINYEIVTSP RGRVVRTYRR ESR 383
    Length:383
    Mass (Da):40,596
    Last modified:February 6, 2007 - v1
    Checksum:i15FE4CBBB7D4C283
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000518 Genomic DNA. Translation: ABL90376.1.
    RefSeqiYP_937166.1. NC_008705.1.

    Genome annotation databases

    EnsemblBacteriaiABL90376; ABL90376; Mkms_1163.
    GeneIDi4614541.
    KEGGimkm:Mkms_1163.
    PATRICi18101269. VBIMycSp70743_1681.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000518 Genomic DNA. Translation: ABL90376.1 .
    RefSeqi YP_937166.1. NC_008705.1.

    3D structure databases

    ProteinModelPortali A1UC18.
    SMRi A1UC18. Positions 12-379.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 189918.Mkms_1163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL90376 ; ABL90376 ; Mkms_1163 .
    GeneIDi 4614541.
    KEGGi mkm:Mkms_1163.
    PATRICi 18101269. VBIMycSp70743_1681.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi GHTWTAQ.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MSP189918:GH4X-1171-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KMSImported.

    Entry informationi

    Entry nameiA1UC18_MYCSK
    AccessioniPrimary (citable) accession number: A1UC18
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3