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Protein

Alanine racemase

Gene

Mkms_1163

Organism
Mycobacterium sp. (strain KMS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei140 – 1401SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMSP189918:GH4X-1171-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Mkms_1163Imported
OrganismiMycobacterium sp. (strain KMS)Imported
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000638: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi189918.Mkms_1163.

Structurei

3D structure databases

ProteinModelPortaliA1UC18.
SMRiA1UC18. Positions 12-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1UC18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTSETTVTP TAQVVVDLDA ISHNVALLRD RAGSAQVMPV LKADGYGHGA
60 70 80 90 100
TEVAKVVLDA GVTELGVATV GEALALRADG ITAPVLAWLH GPGTDFAPAV
110 120 130 140 150
QADIQLAVSS VRQLGEILDA VHRTGMTATL TVKADTGLSR NGVSPAEYPA
160 170 180 190 200
LLQRLAKAQA EDAVRVRGIM SHLACGDEPD NPTNDRQAQR LTDMRRQAAD
210 220 230 240 250
AGVTFEVAHL CNSPAAMTRP DLAFDMVRPG IAVYGQTPIP ALGDMGLRPA
260 270 280 290 300
MTLRCPVAQT RSIKAGDGVS YGHTWIAQRD TTVALLPIGY ADGVYRSLSG
310 320 330 340 350
RLQVLINGRL RPGVGRICMD QFVVDLGPGP VDVSDGDEAI LFGPGTRGEH
360 370 380
TAQDWAEIIG TINYEIVTSP RGRVVRTYRR ESR
Length:383
Mass (Da):40,596
Last modified:February 6, 2007 - v1
Checksum:i15FE4CBBB7D4C283
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL90376.1.
RefSeqiYP_937166.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL90376; ABL90376; Mkms_1163.
GeneIDi4614541.
KEGGimkm:Mkms_1163.
PATRICi18101269. VBIMycSp70743_1681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL90376.1.
RefSeqiYP_937166.1. NC_008705.1.

3D structure databases

ProteinModelPortaliA1UC18.
SMRiA1UC18. Positions 12-379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi189918.Mkms_1163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL90376; ABL90376; Mkms_1163.
GeneIDi4614541.
KEGGimkm:Mkms_1163.
PATRICi18101269. VBIMycSp70743_1681.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMSP189918:GH4X-1171-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KMSImported.

Entry informationi

Entry nameiA1UC18_MYCSK
AccessioniPrimary (citable) accession number: A1UC18
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 4, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.