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Protein

Translation initiation factor IF-1

Gene

infA

Organism
Mycobacterium sp. (strain KMS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor, RNA-binding, rRNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-1UniRule annotation
Gene namesi
Name:infAUniRule annotation
Ordered Locus Names:Mkms_1125
OrganismiMycobacterium sp. (strain KMS)
Taxonomic identifieri189918 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000638 Componenti: Chromosome

Subcellular locationi

A1UBY0:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003388641 – 73Translation initiation factor IF-1Add BLAST73

Interactioni

Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1UBY0.
SMRiA1UBY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73S1-likeUniRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the IF-1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221323.
KOiK02518.
OMAiAHVSGKM.
OrthoDBiPOG091H019C.

Family and domain databases

CDDicd04451. S1_IF1. 1 hit.
HAMAPiMF_00075. IF_1. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR004368. TIF_IF1.
PfamiView protein in Pfam
PF01176. eIF-1a. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00008. infA. 1 hit.
PROSITEiView protein in PROSITE
PS50832. S1_IF1_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UBY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKDGAIEV EGRVVEPLPN AMFRIELENG HKVLAHISGK MRQHYIRILP
60 70
EDRVVVELSP YDLSRGRIVY RYK
Length:73
Mass (Da):8,489
Last modified:February 6, 2007 - v1
Checksum:i70CEB2A79E874448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000518 Genomic DNA. Translation: ABL90338.1.
RefSeqiWP_003418601.1. NC_008705.1.

Genome annotation databases

EnsemblBacteriaiABL90338; ABL90338; Mkms_1125.
GeneIDi4223708.
KEGGimkm:Mkms_1125.

Similar proteinsi

Entry informationi

Entry nameiIF1_MYCSK
AccessioniPrimary (citable) accession number: A1UBY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 6, 2007
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families