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A1UBR8 (A1UBR8_MYCSK) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein translocase subunit SecY RuleBase RU000537 HAMAP-Rule MF_01465
Gene names
Name:secY HAMAP-Rule MF_01465
Ordered Locus Names:Mkms_1062 EMBL ABL90276.1
OrganismMycobacterium sp. (strain KMS) [Complete proteome] [HAMAP] EMBL ABL90276.1
Taxonomic identifier189918 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity. RuleBase RU000537 HAMAP-Rule MF_01465

Subunit structure

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity. HAMAP-Rule MF_01465

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01465.

Membrane; Multi-pass membrane protein By similarity RuleBase RU003484.

Sequence similarities

Belongs to the SecY/SEC61-alpha family. HAMAP-Rule MF_01465 RuleBase RU004349

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane78 – 9821Helical; By similarity HAMAP-Rule MF_01465
Transmembrane124 – 14421Helical; By similarity HAMAP-Rule MF_01465
Transmembrane157 – 17721Helical; By similarity HAMAP-Rule MF_01465
Transmembrane185 – 20521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane215 – 23521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane272 – 29221Helical; By similarity HAMAP-Rule MF_01465
Transmembrane320 – 34021Helical; By similarity HAMAP-Rule MF_01465
Transmembrane378 – 39821Helical; By similarity HAMAP-Rule MF_01465
Transmembrane401 – 42121Helical; By similarity HAMAP-Rule MF_01465

Sequences

Sequence LengthMass (Da)Tools
A1UBR8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 5F58CC3CFCD0FF6A

FASTA44147,554
        10         20         30         40         50         60 
MLSAFISSLR TADLRRKILF TLGVVLLYRV GASLPSPGVN YPNVQECIAQ VSGGESGQIY 

        70         80         90        100        110        120 
SLINLFSGGA LLQLSVFAVG VMPYITASII VQLLTVVIPR FEQLRKEGQA GQSKMTQYTR 

       130        140        150        160        170        180 
YLAVALAVLQ STSIVALAAN GGLLQGCALD IIEDQAIFSL LVIVLVMTAG ASLVMWMGEL 

       190        200        210        220        230        240 
VTERGIGNGM SLIIFASIAA AMPGEGKSIL DSRGGMVFAA VCAGALIIII GVVFVEQGQR 

       250        260        270        280        290        300 
RIPVQYAKRM VGRRMYGGTS TYLPLKVNQA GVIPVIFASS LIYIPHLVTQ LIQSGSSNPG 

       310        320        330        340        350        360 
TGWWERFVAE YLTDPSSPWY IGIYFALIIF FTYFYVSITF NPDERADEMK KFGGFIPGIR 

       370        380        390        400        410        420 
PGKPTADYLR YVLSRITLPG SIYLGLIAVL PNLFANVGSS GPVQNLPFGG VGVLIMIGVG 

       430        440 
LDTVKQIESQ LMQRNYEGFL K

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References

[1]"Complete sequence of chromosome of Mycobacterium sp. KMS."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KMS EMBL ABL90276.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000518 Genomic DNA. Translation: ABL90276.1.
RefSeqYP_937066.1. NC_008705.1.

3D structure databases

ProteinModelPortalA1UBR8.
ModBaseSearch...

Protein-protein interaction databases

STRING189918.Mkms_1062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL90276; ABL90276; Mkms_1062.
GeneID4614583.
KEGGmkm:Mkms_1062.
PATRIC18101064. VBIMycSp70743_1579.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0201.
HOGENOMHOG000080586.
KOK03076.
OMAFIMWLGE.
ProtClustDBPRK09204.

Enzyme and pathway databases

BioCycMSP189918:GH4X-1119-MONOMER.

Family and domain databases

Gene3D1.10.3370.10. 1 hit.
HAMAPMF_01465. SecY.
InterProIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERPTHR10906. PTHR10906. 1 hit.
PfamPF00344. SecY. 1 hit.
[Graphical view]
PIRSFPIRSF004557. SecY. 1 hit.
SUPFAMSSF103491. SecY. 1 hit.
TIGRFAMsTIGR00967. 3a0501s007. 1 hit.
PROSITEPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1UBR8_MYCSK
AccessionPrimary (citable) accession number: A1UBR8
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info