A1U8S6 (A1U8S6_MYCSK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA gyrase subunit A EMBL ABL89234.1
EC=5.99.1.3 EMBL ABL89234.1

Gene names

Ordered Locus Names:

Mkms_0015

Organism

Mycobacterium sp. (strain KMS) [Complete proteome] [HAMAP]

Taxonomic identifier

189918 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691
Subcellular location	Cytoplasm By similarity SAAS SAAS006691.

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691
Ligand	ATP-binding SAAS SAAS006691 DNA-binding SAAS SAAS006691 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro intein-mediated protein splicing Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: EC endonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1U8S6 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: A2D5CC8E4F07F20E	FASTA	1,257	139,129
	10 20 30 40 50 60 MTDTTLPPGD EAGDRIEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM 70 80 90 100 110 120 FDSGFRPDRG HAKSARSVAE TMGNYHPHGD SSIYDTLVRM AQPWSLRYPL VDGQGNFGSP 130 140 150 160 170 180 GNDPPAAMRY CVTGDALVRL PLGQSVRIDG VVPGAKPNSD NPIDLKVVDR HGDPVAADRL 190 200 210 220 230 240 FHSGEHQTYK VTTTEGYTVT GTENHPLLCL VDVGGVPTLL WKLVEEIRPG DTVVLQRSQP 250 260 270 280 290 300 MEFGPADWQE TLEALLAGAF ISEGFISEKR AGFNNLDRDF FNMVVAAYDA VVGGRRYVSS 310 320 330 340 350 360 RTIASGSLLH ELDIHNLESL RRSRLGVAVG QRSADKFVPE WIWQSPAAVK RVFLQALFEG 370 380 390 400 410 420 DGSCSRLPRN TIQVSYSTRS ERLAADVQQM LLEFGIVSRR YRHAVGEYKV ALTNRAQAEL 430 440 450 460 470 480 FARQIGFGGA KQVKLLEILS ALPEEAAGLD RDFVPGLARF IRQHSGGRWA DKEWLRKHNV 490 500 510 520 530 540 DRISRWQRNG AEILGRIADP EVRAVATDLT DGRFYYATVA SVADAGVQPV YSLRVDTEDH 550 560 570 580 590 600 AFITNGFVSH NTEARLTPLA MEMLREIDEE TVDFIPNYDG RVQEPTVLPS RFPNLLANGS 610 620 630 640 650 660 GGIAVGMATN IPPHNLRELA DAVYWCLENF EADEETTLAA VMERVKGPDF PTHGLIVGSQ 670 680 690 700 710 720 GIEDTYKTGR GSVKMRGVVE IEEDSRGRTG IVITELPYQV NHDNFITSIA EQVRDGKLAG 730 740 750 760 770 780 ISNIEDQSSD RVGLRIVVEL KRDAVAKVVL NNLYKHTQLQ TSFGANMLSI VDGVPRTLRL 790 800 810 820 830 840 DQMIRYYVEH QLDVIVRRTR YRLRKANERA HILRGLVKAL DALDEVIALI RASQTVDIAR 850 860 870 880 890 900 AGLIELLDID EIQAQAILDM QLRRLAALER QRIVDDLAKI EAEIADLEDI LAKPERQRAI 910 920 930 940 950 960 VRDELKEIAD KYGDDRRTRI VPADGEVSDE DLIAREDVVV TITETGYAKR TKTDLYRSQK 970 980 990 1000 1010 1020 RGGKGVQGAG LKQDDIVNHF FVCSTHDWIL FFTTQGRVYR AKAYELPEAS RTARGQHVAN 1030 1040 1050 1060 1070 1080 LLAFQPNERI AQVIQIKSYE DAPYLVLATR NGLVKKSRLT DFDSNRSGGI VAVNLRDGDE 1090 1100 1110 1120 1130 1140 LVGAVLCSSE DDLLLVSAKG QSIRFSATDE ALRPMGRATS GVQGMRFNAD DELLSLNVVR 1150 1160 1170 1180 1190 1200 PDTYLLVATS GGYAKRTSIE EYTAQGRGGK GILTIQYDRR RGNLVGALIV DDDTELYAIT 1210 1220 1230 1240 1250 SGGGVIRTAA RQVRKAGRQT KGVRLMNLGE GDTLIAIARN AEAGDSTDEV NTDPDAV

References

[1]

"Complete sequence of chromosome of Mycobacterium sp. KMS." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KMS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000518 Genomic DNA. Translation: ABL89234.1.
RefSeq	YP_936024.1. NC_008705.1.
3D structure databases
ProteinModelPortal	A1U8S6.
SMR	A1U8S6. Positions 38-130, 132-254, 499-551.
ModBase	Search...
Protein-protein interaction databases
STRING	A1U8S6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000055675; EBMYCP00000053899; EBMYCG00000055670.
GeneID	4615579.
GenomeReviews	Gene locus Mkms_0015 in contig CP000518_GR.
KEGG	mkm:Mkms_0015.
PATRIC	18098954. VBIMycSp70743_0532.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
GeneTree	EBGT00050000016653.
HOGENOM	HBG635183.
OMA	TGRGRIY.
ProtClustDB	CLSK701787.
Family and domain databases
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR003586. Hedgehog_hint_C. IPR003587. Hedgehog_hint_N. IPR006142. INTEIN. IPR004042. Intein_endonuc. IPR006141. Intein_splice_site. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 2 hits. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 2 hits. [Graphical view]
PRINTS	PR00379. INTEIN.
SMART	SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 2 hits.
TIGRFAMs	TIGR01063. GyrA. 1 hit. TIGR01443. Intein_Cterm. 1 hit. TIGR01445. Intein_Nterm. 1 hit.
PROSITE	PS50818. INTEIN_C_TER. 1 hit. PS50819. INTEIN_ENDONUCLEASE. 1 hit. PS50817. INTEIN_N_TER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1U8S6_MYCSK

Accession

Primary (citable) accession number: A1U8S6

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)