A1U7E0 (A1U7E0_MARAV) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Choline dehydrogenase HAMAP MF_00750
Short name=CDH HAMAP MF_00750
Short name=CHD HAMAP MF_00750
EC=1.1.99.1 HAMAP MF_00750

Gene names

Name:	betA HAMAP MF_00750
Ordered Locus Names:	Maqu_3840

Organism

Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) [Complete proteome] [HAMAP] EMBL ABM20909.1

Taxonomic identifier

351348 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Marinobacter

Protein attributes

Sequence length	561 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750 SAAS SAAS007867
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750 SAAS SAAS007867
Cofactor	FAD By similarity. HAMAP MF_00750 SAAS SAAS007867
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750 SAAS SAAS007867
Sequence similarities	Belongs to the GMC oxidoreductase family. HAMAP MF_00750

Ontologies

Keywords
Ligand	FAD HAMAP MF_00750 SAAS SAAS011533 Flavoprotein HAMAP MF_00750 SAAS SAAS011533
Molecular function	Oxidoreductase HAMAP MF_00750 SAAS SAAS007867 EMBL ABM20909.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	7 – 36	30	FAD By similarity HAMAP MF_00750
Sites
	Active site	470	1	By similarity HAMAP MF_00750

Sequences

	Sequence		Length	Mass (Da)
	A1U7E0 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: B060056D28ED42D5	FASTA	561	62,665
	10 20 30 40 50 60 MKENQYDYII VGAGSAGCVL ANRLTEDSEN RVLLLETGGS DKSIFIQMPT ALSIPMNTKK 70 80 90 100 110 120 YAWQFETEPE PYLDNRRMHC PRGKVLGGSS SINGMVYVRG HARDFDEWQS EGADGWNYRN 130 140 150 160 170 180 VLPYFKKAET WAFGGDAYRG NSGPLGVNNG NNMRNPLYTA FIRAGVDAGY LETDDYNGAR 190 200 210 220 230 240 QEGFGAMHMT VKNGRRWSTA NAYLRPAMAR PNLTVVTHAL VHKVLLEGKT ATGVRYEQGG 250 260 270 280 290 300 QVHEAKAAKE VILSAGSIGS PHLLQLSGIG KREVLEQAGI EVKHELPGVG ENLQDHLEFY 310 320 330 340 350 360 FQFRCQKPVS LNGKLDWWNK LKIGVRWILR KDGLGATNHF ESCGFIRSKA GVEWPDLQYH 370 380 390 400 410 420 FLPAAMRYDG REAFDGDGFQ LHIGHNKPKS RGFVHVQSAD PKQAPRIRFN YLEHEADREG 430 440 450 460 470 480 FRDCVRLTRE IINQPAMDEY RGAEIQPGVD VQSDEQIDAF VRQAVESAYH PSCSCKMGTD 490 500 510 520 530 540 ALAVVDPETR VRGIQNLRVV DSSIFPTIPN GNLNAPTIMV AERAADLIRG REPLQPSDAP 550 560 VFMDDQWQAR QRPGQAKRSL A

References

[1]

"Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000514 Genomic DNA. Translation: ABM20909.1.
RefSeq	YP_961096.1. NC_008740.1.
3D structure databases
ProteinModelPortal	A1U7E0.
ModBase	Search...
Protein-protein interaction databases
STRING	A1U7E0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4655315.
GenomeReviews	Gene locus Maqu_3840 in contig CP000514_GR.
KEGG	maq:Maqu_3840.
PATRIC	22463066. VBIMarAqu65105_4273.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2303.
HOGENOM	HBG734713.
OMA	HMTVKNG.
PhylomeDB	A1U7E0.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1U7E0_MARAV

Accession

Primary (citable) accession number: A1U7E0

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)