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A1U6U1 (UPPP_MARAV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Maqu_3641
OrganismMarinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) [Complete proteome] [HAMAP]
Taxonomic identifier351348 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290725

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane244 – 26421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1U6U1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: D5F5F64C010A6A64

FASTA26528,784
        10         20         30         40         50         60 
MDIFQALFLG LLQGLTEFLP ISSSAHLILT PAFFGWEDQG VGFDLSVHVG TLLAVVLYFR 

        70         80         90        100        110        120 
RDVFGIARDG LISMGQRKIV GQGALAWYLV IGTIPAGLAG LALLDMIDNE LRGASVIFFT 

       130        140        150        160        170        180 
TLVFGILLGI ADWLPKRQRT MDSLNWKDAV IVGIAQAMAL VPGTSRSGVT ITAGLFLGMT 

       190        200        210        220        230        240 
RETASRFSFL LAIPIIVLAS AVKLLEVATS DVIVDWNGFL IGGVTSFLMA ITAIHFFLKW 

       250        260 
LNKVGMWPYV IYRIILAGVI YAVLM 

« Hide

References

[1]"Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700491 / DSM 11845 / VT8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000514 Genomic DNA. Translation: ABM20710.1.
RefSeqYP_960897.1. NC_008740.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351348.Maqu_3641.

Protocols and materials databases

DNASU4654020.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM20710; ABM20710; Maqu_3641.
GeneID4654020.
KEGGmaq:Maqu_3641.
PATRIC22462656. VBIMarAqu65105_4068.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMASDIMRIA.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycMHYD351348:GHYZ-3703-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_MARAV
AccessionPrimary (citable) accession number: A1U6U1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families