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A1U6F9

- PDXA_MARAV

UniProt

A1U6F9 - PDXA_MARAV

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei135 – 1351SubstrateUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Metal bindingi165 – 1651Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi210 – 2101Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi265 – 2651Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei273 – 2731SubstrateUniRule annotation
    Binding sitei282 – 2821SubstrateUniRule annotation
    Binding sitei291 – 2911SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    BioCyciMHYD351348:GHYZ-3570-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:Maqu_3508
    OrganismiMarinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845))
    Taxonomic identifieri351348 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
    ProteomesiUP000000998: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3363364-hydroxythreonine-4-phosphate dehydrogenasePRO_1000051507Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi351348.Maqu_3508.

    Structurei

    3D structure databases

    ProteinModelPortaliA1U6F9.
    SMRiA1U6F9. Positions 7-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221592.
    KOiK00097.
    OMAiIMANEMA.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1U6F9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTPVILALT AGEPAGIGPE LCLQLATGSR DAGLVVIASG ELLRDRASQL    50
    GLQIELHDWQ PGVAAATRAG HLSVRHVEGC GSTVAGRLDK ANSQYVLDTL 100
    TIAARGCLNG DFDGMVTAPV HKGVINEAGI VFSGHTEFLQ ELCGVERVVM 150
    MLATEELRVA LVTTHLPLKD VSAAITPDRL TQVTRILNAD LKAFFGIDQP 200
    RILVAGLNPH AGEGGHLGRE EIEVIEPTLE QLRAEGIQLT GPLPADTLFT 250
    PHWLDNADAV LAMYHDQGLP VLKFQGFGRA VNITLGLPIV RTSVDHGTAL 300
    DLAGTGKADA GSLHTAIRVG EQMAQCRKAT GAGELS 336
    Length:336
    Mass (Da):35,346
    Last modified:February 6, 2007 - v1
    Checksum:iEEBB9ED10E708F1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000514 Genomic DNA. Translation: ABM20578.1.
    RefSeqiYP_960765.1. NC_008740.1.

    Genome annotation databases

    EnsemblBacteriaiABM20578; ABM20578; Maqu_3508.
    GeneIDi4657262.
    KEGGimaq:Maqu_3508.
    PATRICi22462380. VBIMarAqu65105_3930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000514 Genomic DNA. Translation: ABM20578.1 .
    RefSeqi YP_960765.1. NC_008740.1.

    3D structure databases

    ProteinModelPortali A1U6F9.
    SMRi A1U6F9. Positions 7-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351348.Maqu_3508.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM20578 ; ABM20578 ; Maqu_3508 .
    GeneIDi 4657262.
    KEGGi maq:Maqu_3508.
    PATRICi 22462380. VBIMarAqu65105_3930.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221592.
    KOi K00097.
    OMAi IMANEMA.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci MHYD351348:GHYZ-3570-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
      , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700491 / DSM 11845 / VT8.

    Entry informationi

    Entry nameiPDXA_MARAV
    AccessioniPrimary (citable) accession number: A1U6F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3