Reviewed, UniProtKB/Swiss-Prot A1U5W8 (ASTD_MARAV)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Maqu_3316

Organism

Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) [Complete proteome] [HAMAP]

Taxonomic identifier

351348 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Marinobacter

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_1000138051
Regions
	Nucleotide binding	225 – 230	6	NAD By similarity
Sites
	Active site	248	1	By similarity
	Active site	282	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1U5W8-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 52F36E678DD2AED1	FASTA	491	52,483
	10 20 30 40 50 60 MANLTGNVYI DGLWLPGHGA PFESVQPVTG ETVWDGNAAS LEDVDAAVRE ARKAFLAWRR 70 80 90 100 110 120 KSLAERQAVI EAFGELLEAN KEELAHQIGL ETGKPLWESR TEVAAMMGKI PISVKAYNER 130 140 150 160 170 180 TGHTESDVAG GHAVLRHRPH GVVAVFGPYN FPGHLPNGHI VPALLAGNTV VFKPSELTPG 190 200 210 220 230 240 VAELTVRLWE KAGLPDGVIN LVQGGSDTGK CLARHSLIDG LFFTGSSTVG HLLHEQFGGQ 250 260 270 280 290 300 PEKILALEMG GNNPLIVQNV SDLDGAVHHA LQSAFLSAGQ RCTCARRLLV PKGKKGDEFL 310 320 330 340 350 360 ARLVEVAARI TVAEFDADPQ PFMGSVISAE AANQLLKAQA AMLEKGATSL LEMKQLKPDT 370 380 390 400 410 420 GLLSPGIVDA TGIELEDQEF FGPLLTVYRY KGFDEALELA NNTRYGLSAG ILSDDRKLYN 430 440 450 460 470 480 RLVEEVRAGI VNWNRPLTGA SSAAPFGGVG ASGNHRPSAY YAADYCAWPM ASLEAGKSEL 490 PDSLAPGLNF D

References

[1]

"Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000514 Genomic DNA. Translation: ABM20387.1.
RefSeq	YP_960574.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1U5W8.
Genome annotation databases
GeneID	4653619.
GenomeReviews	Gene locus Maqu_3316 in contig CP000514_GR.
KEGG	maq:Maqu_3316.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IRAHDER.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_MARAV

Accession

Primary (citable) accession number: A1U5W8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)