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A1U4A0

- SYL_MARAV

UniProt

A1U4A0 - SYL_MARAV

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Protein

Leucine--tRNA ligase

Gene
leuS, Maqu_2744
Organism
Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMHYD351348:GHYZ-2803-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Maqu_2744
OrganismiMarinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845))
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
ProteomesiUP000000998: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Leucine--tRNA ligaseUniRule annotationPRO_0000334770Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351348.Maqu_2744.

Structurei

3D structure databases

ProteinModelPortaliA1U4A0.
SMRiA1U4A0. Positions 229-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi620 – 6245"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1U4A0-1 [UniParc]FASTAAdd to Basket

« Hide

MDEQYNPREV EQTARTFWET NETFKVKEEP GKPKYYCLSM FPYPSGKLHM    50
GHVRNYTIGD VISRYQRMQG KNVMQPMGWD AFGLPAENAA IANKSAPAKW 100
TRSNIDYMKN QLKQLGFGYD WSRELATCDP EYYRWEQWFF ARLYEKGLVY 150
KKMSTVNWDP VDQTVLANEQ VVDGRGWRSG ALVEQKKIPQ WFIRITDYAE 200
ELLNDLEDME GWPEQVKTMQ RNWIGKSVGT ELTFPLKEQE GGLTVYTTRP 250
DTLMGVSYMA VAAEHPLAKA AAERHRDVAE FVDQCRNSKV AEAELATMEK 300
KGIDTGFKAI HPLTQEEIPV WVANFVLMDY GTGALMAVPG HDERDHEFAV 350
KYKLPIKQVI APNDSRDIDI QEQAFTEKGV LVSSGKYSGL TSEEAFEEIA 400
DYLEAQGIGK RTVNYRLRDW GVSRQRYWGA PIPMMTLEDG TEMPVPDDQL 450
PVRLPEDVEM DGVQSPIKAD PEWCKTEYNG QPATLETDTF DTFMESSWYY 500
ARFCSPNYDK GMLDPAAANY WLPVDQYIGG IEHAILHLLY ARFFHKLLRD 550
VGLVNSSEPF KRLLTQGMVL AETYYRNEAN GGKTWYNPAD VTVERDGKGQ 600
VVRAVLKSDG EPVEIGGVTK MSKSKNNGID PQAIIDQHGA DTVRLFMMFA 650
APPEQSLEWS DSGVEGAHRF LKRLWRMVNE HTAGGDAPAV DPANLNGAQK 700
DLRRKTHETI AKVSDDISRR LTFNTAIAAV MELLNEVGRL SDDEPQSRAV 750
RQEALDTAVL VLSPIVPHIC HNLWQALGHS DAVVDASWPV ADESAMVRSE 800
IEVVLQVNGK VRAKENVPAD IGKADLEKLA LENENVMRFT DGKTVRKVIV 850
VPGKLVNVVA N 861
Length:861
Mass (Da):97,230
Last modified:May 20, 2008 - v2
Checksum:i0C308BF782455E9A
GO

Sequence cautioni

The sequence ABM19819.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000514 Genomic DNA. Translation: ABM19819.1. Different initiation.
RefSeqiYP_960006.1. NC_008740.1.

Genome annotation databases

EnsemblBacteriaiABM19819; ABM19819; Maqu_2744.
GeneIDi4654614.
KEGGimaq:Maqu_2744.
PATRICi22460834. VBIMarAqu65105_3159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000514 Genomic DNA. Translation: ABM19819.1 . Different initiation.
RefSeqi YP_960006.1. NC_008740.1.

3D structure databases

ProteinModelPortali A1U4A0.
SMRi A1U4A0. Positions 229-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351348.Maqu_2744.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM19819 ; ABM19819 ; Maqu_2744 .
GeneIDi 4654614.
KEGGi maq:Maqu_2744.
PATRICi 22460834. VBIMarAqu65105_3159.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MHYD351348:GHYZ-2803-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700491 / DSM 11845 / VT8.

Entry informationi

Entry nameiSYL_MARAV
AccessioniPrimary (citable) accession number: A1U4A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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