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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei623ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Maqu_2744
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000000998 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347701 – 861Leucine--tRNA ligaseAdd BLAST861

Interactioni

Protein-protein interaction databases

STRINGi351348.Maqu_2744

Structurei

3D structure databases

ProteinModelPortaliA1U4A0
SMRiA1U4A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi620 – 624"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1U4A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQYNPREV EQTARTFWET NETFKVKEEP GKPKYYCLSM FPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMQG KNVMQPMGWD AFGLPAENAA IANKSAPAKW
110 120 130 140 150
TRSNIDYMKN QLKQLGFGYD WSRELATCDP EYYRWEQWFF ARLYEKGLVY
160 170 180 190 200
KKMSTVNWDP VDQTVLANEQ VVDGRGWRSG ALVEQKKIPQ WFIRITDYAE
210 220 230 240 250
ELLNDLEDME GWPEQVKTMQ RNWIGKSVGT ELTFPLKEQE GGLTVYTTRP
260 270 280 290 300
DTLMGVSYMA VAAEHPLAKA AAERHRDVAE FVDQCRNSKV AEAELATMEK
310 320 330 340 350
KGIDTGFKAI HPLTQEEIPV WVANFVLMDY GTGALMAVPG HDERDHEFAV
360 370 380 390 400
KYKLPIKQVI APNDSRDIDI QEQAFTEKGV LVSSGKYSGL TSEEAFEEIA
410 420 430 440 450
DYLEAQGIGK RTVNYRLRDW GVSRQRYWGA PIPMMTLEDG TEMPVPDDQL
460 470 480 490 500
PVRLPEDVEM DGVQSPIKAD PEWCKTEYNG QPATLETDTF DTFMESSWYY
510 520 530 540 550
ARFCSPNYDK GMLDPAAANY WLPVDQYIGG IEHAILHLLY ARFFHKLLRD
560 570 580 590 600
VGLVNSSEPF KRLLTQGMVL AETYYRNEAN GGKTWYNPAD VTVERDGKGQ
610 620 630 640 650
VVRAVLKSDG EPVEIGGVTK MSKSKNNGID PQAIIDQHGA DTVRLFMMFA
660 670 680 690 700
APPEQSLEWS DSGVEGAHRF LKRLWRMVNE HTAGGDAPAV DPANLNGAQK
710 720 730 740 750
DLRRKTHETI AKVSDDISRR LTFNTAIAAV MELLNEVGRL SDDEPQSRAV
760 770 780 790 800
RQEALDTAVL VLSPIVPHIC HNLWQALGHS DAVVDASWPV ADESAMVRSE
810 820 830 840 850
IEVVLQVNGK VRAKENVPAD IGKADLEKLA LENENVMRFT DGKTVRKVIV
860
VPGKLVNVVA N
Length:861
Mass (Da):97,230
Last modified:May 20, 2008 - v2
Checksum:i0C308BF782455E9A
GO

Sequence cautioni

The sequence ABM19819 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000514 Genomic DNA Translation: ABM19819.1 Different initiation.
RefSeqiWP_041656989.1, NC_008740.1

Genome annotation databases

EnsemblBacteriaiABM19819; ABM19819; Maqu_2744
KEGGimaq:Maqu_2744

Similar proteinsi

Entry informationi

Entry nameiSYL_MARHV
AccessioniPrimary (citable) accession number: A1U4A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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