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A1U3F8 (MURG_MARAV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:Maqu_2452
OrganismMarinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) [Complete proteome] [HAMAP]
Taxonomic identifier351348 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP-Rule MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP-Rule MF_00033
PRO_0000315115

Sequences

Sequence LengthMass (Da)Tools
A1U3F8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 6C0C926CF47BEB0B

FASTA36339,029
        10         20         30         40         50         60 
MTDSPRRRFL MMAGGTGGHV FPALATARAL QQRGHEVHWL GASGGMEERL IGDTDIPLSL 

        70         80         90        100        110        120 
IHISGLRGKG KLALLLAPFR LMRALGEAYT HLRRIRPDCV VGMGGFVTGP GGIAAWLMRK 

       130        140        150        160        170        180 
PLVIHEQNAI AGMTNRWLTR FSETVLEAFP GSFGDQTVTR CTGNPVRGEV ASMDEPEQRL 

       190        200        210        220        230        240 
AGRSGKLRVL VVGGSLGAQV FNQQLPQALA LMPEADRPDV RHQCGEKNLE AAQAAYEEAG 

       250        260        270        280        290        300 
VNASVEPFIR DMAEAYGWAD LVICRAGALT VSELCAAGIG AILVPFPHAV DDHQTRNGQH 

       310        320        330        340        350        360 
MVKAGAAILV PQPRLTPEVL AETLKDLATD RKRILTMAKA ARSLARPDAT ERVVNYCLEA 


ANG 

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References

[1]"Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700491 / DSM 11845 / VT8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000514 Genomic DNA. Translation: ABM19527.1.
RefSeqYP_959714.1. NC_008740.1.

3D structure databases

ProteinModelPortalA1U3F8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351348.Maqu_2452.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM19527; ABM19527; Maqu_2452.
GeneID4656931.
KEGGmaq:Maqu_2452.
PATRIC22460246. VBIMarAqu65105_2872.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0707.
HOGENOMHOG000218321.
KOK02563.
OMAEDHQTKN.
OrthoDBEOG61VZFD.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycMHYD351348:GHYZ-2503-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00033. MurG.
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
IPR006311. TAT_signal.
[Graphical view]
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. murG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_MARAV
AccessionPrimary (citable) accession number: A1U3F8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways