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A1U3F8

- MURG_MARHV

UniProt

A1U3F8 - MURG_MARHV

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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Source: UniProtKB-EC
  3. undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. lipid glycosylation Source: UniProtKB-HAMAP
  5. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
  7. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMHYD351348:GHYZ-2503-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:Maqu_2452
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
ProteomesiUP000000998: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000315115Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351348.Maqu_2452.

Structurei

3D structure databases

ProteinModelPortaliA1U3F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0707.
HOGENOMiHOG000218321.
KOiK02563.
OMAiPFIKDMA.
OrthoDBiEOG61VZFD.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

A1U3F8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDSPRRRFL MMAGGTGGHV FPALATARAL QQRGHEVHWL GASGGMEERL
60 70 80 90 100
IGDTDIPLSL IHISGLRGKG KLALLLAPFR LMRALGEAYT HLRRIRPDCV
110 120 130 140 150
VGMGGFVTGP GGIAAWLMRK PLVIHEQNAI AGMTNRWLTR FSETVLEAFP
160 170 180 190 200
GSFGDQTVTR CTGNPVRGEV ASMDEPEQRL AGRSGKLRVL VVGGSLGAQV
210 220 230 240 250
FNQQLPQALA LMPEADRPDV RHQCGEKNLE AAQAAYEEAG VNASVEPFIR
260 270 280 290 300
DMAEAYGWAD LVICRAGALT VSELCAAGIG AILVPFPHAV DDHQTRNGQH
310 320 330 340 350
MVKAGAAILV PQPRLTPEVL AETLKDLATD RKRILTMAKA ARSLARPDAT
360
ERVVNYCLEA ANG
Length:363
Mass (Da):39,029
Last modified:February 6, 2007 - v1
Checksum:i6C0C926CF47BEB0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000514 Genomic DNA. Translation: ABM19527.1.
RefSeqiYP_959714.1. NC_008740.1.

Genome annotation databases

EnsemblBacteriaiABM19527; ABM19527; Maqu_2452.
GeneIDi4656931.
KEGGimaq:Maqu_2452.
PATRICi22460246. VBIMarAqu65105_2872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000514 Genomic DNA. Translation: ABM19527.1 .
RefSeqi YP_959714.1. NC_008740.1.

3D structure databases

ProteinModelPortali A1U3F8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351348.Maqu_2452.

Protein family/group databases

CAZyi GT28. Glycosyltransferase Family 28.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM19527 ; ABM19527 ; Maqu_2452 .
GeneIDi 4656931.
KEGGi maq:Maqu_2452.
PATRICi 22460246. VBIMarAqu65105_2872.

Phylogenomic databases

eggNOGi COG0707.
HOGENOMi HOG000218321.
KOi K02563.
OMAi PFIKDMA.
OrthoDBi EOG61VZFD.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci MHYD351348:GHYZ-2503-MONOMER.

Family and domain databases

HAMAPi MF_00033. MurG.
InterProi IPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01133. murG. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
    , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700491 / DSM 11845 / VT8.

Entry informationi

Entry nameiMURG_MARHV
AccessioniPrimary (citable) accession number: A1U3F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3