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Protein

Alanine racemase

Gene

alr

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei128SubstrateUniRule annotation1
Active sitei254Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei302Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:Maqu_2381
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000000998 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000660081 – 357Alanine racemaseAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi351348.Maqu_2381

Structurei

3D structure databases

ProteinModelPortaliA1U388
SMRiA1U388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031446
KOiK01775
OMAiISHFACA
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

A1U388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPTVARID LDALKHNFRR ARELAGTAYA MAVVKADGYG HGIRSVADAL
60 70 80 90 100
APETSRFAVA CIEEAIAIRG AGHRHSVVLL QGTHQKDDLA ECERSGFEPV
110 120 130 140 150
LHCQQQLSWL GAGRSPRFWI KVNTGMNRLG FRPEELPEVM AGLEEAGLKH
160 170 180 190 200
LAIGFVTHFA CADDSDSEMT GLQTRIFERA VAPWPDLMRS VGNSAAHFRP
210 220 230 240 250
NQPLYEWSRP GIMLYGASPM EGKTGAELGL CPAMTLQAPL ITTRVVRAGE
260 270 280 290 300
SVGYGASWTA SQDTRMGMVA IGYADGYPRH AGTGTPAAVR GQRIRLLGRV
310 320 330 340 350
SMDMLAVDLS AVPEAREGDM VELWGKTVSV DEVATCAGTI GYELLTGVTS

RVPRVHE
Length:357
Mass (Da):38,607
Last modified:February 6, 2007 - v1
Checksum:iF4DEE09F3350C735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000514 Genomic DNA Translation: ABM19457.1
RefSeqiWP_011785844.1, NC_008740.1

Genome annotation databases

EnsemblBacteriaiABM19457; ABM19457; Maqu_2381
KEGGimaq:Maqu_2381

Similar proteinsi

Entry informationi

Entry nameiALR_MARHV
AccessioniPrimary (citable) accession number: A1U388
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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