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Protein

NAD kinase

Gene

nadK

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptorUniRule annotation1
Binding sitei157NADUniRule annotation1
Binding sitei174NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei247NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 73NADUniRule annotation2
Nucleotide bindingi146 – 147NADUniRule annotation2
Nucleotide bindingi187 – 192NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Maqu_2072
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000000998 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000054221 – 294NAD kinaseAdd BLAST294

Interactioni

Protein-protein interaction databases

STRINGi351348.Maqu_2072

Structurei

3D structure databases

ProteinModelPortaliA1U2D4
SMRiA1U2D4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A1U2D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQFRNIGIV GRMGSVKVVE SLRQLKQYLT ANNYHVIIEE DTSTMIPGHG
60 70 80 90 100
LQVASKKLLG EICDLVIVVG GDGSLLGAAR ELAKSKIPIL GVNRGRLGFL
110 120 130 140 150
TDISPSDLEE RLARVLEGDY IEESRFLLDG HVERNGQPLG YGSALNDVVL
160 170 180 190 200
HPGKSTRMIG FDLFIDGHFV YSQRSDGLIV ATPTGSTAYS LSAGGPIMHP
210 220 230 240 250
KLDAVVLVPM FPHTLSSRPI VVDGKSEIKL VIGETNETYP QVSFDGQMNI
260 270 280 290
ACAPGDIIRI TKKPFKIRLI HPTDHNFYAT CRDKLGWASE IAAS
Length:294
Mass (Da):32,009
Last modified:February 6, 2007 - v1
Checksum:i31A2D7DBA4D39487
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000514 Genomic DNA Translation: ABM19153.1
RefSeqiWP_011785545.1, NC_008740.1

Genome annotation databases

EnsemblBacteriaiABM19153; ABM19153; Maqu_2072
GeneIDi31820698
KEGGimaq:Maqu_2072

Similar proteinsi

Entry informationi

Entry nameiNADK_MARHV
AccessioniPrimary (citable) accession number: A1U2D4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health