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Protein

Bifunctional protein PutA

Gene

Maqu_2049

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Oxidizes proline to glutamate for use as a carbon and nitrogen source.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Bifunctional protein PutA (Maqu_2049)
  2. Bifunctional protein PutA (Maqu_2049)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei785UniRule annotation1
Active sitei819UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, OxidoreductaseUniRule annotationImported, RepressorUniRule annotation
Biological processProline metabolismUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciMAQU351348:G12X6-2071-MONOMER
UniPathwayiUPA00261; UER00373
UPA00261; UER00374

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PutAUniRule annotation
Including the following 2 domains:
Proline dehydrogenaseUniRule annotation (EC:1.5.5.2UniRule annotation)
Alternative name(s):
Proline oxidaseUniRule annotation
Delta-1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Ordered Locus Names:Maqu_2049Imported
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)Imported
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000000998 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi351348.Maqu_2049

Structurei

3D structure databases

ProteinModelPortaliA1U2B1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 178Pro_dh-DNA_bdgInterPro annotationAdd BLAST112
Domaini190 – 481Pro_dhInterPro annotationAdd BLAST292
Domaini562 – 1005AldedhInterPro annotationAdd BLAST444

Sequence similaritiesi

In the C-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the proline dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG0506 LUCA
COG4230 LUCA
HOGENOMiHOG000253911
KOiK13821
OMAiVRIYAPV
OrthoDBiPOG091H043M

Family and domain databases

Gene3Di3.40.309.101 hit
3.40.605.102 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR025703 Bifunct_PutA
IPR005933 Delta1-pyrroline-5-COlate_DH-3
IPR029041 FAD-linked_oxidoreductase-like
IPR024089 PRODH_PutA_dom_I/II
IPR024082 PRODH_PutA_dom_II
IPR002872 Proline_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF01619 Pro_dh, 1 hit
PF14850 Pro_dh-DNA_bdg, 1 hit
PIRSFiPIRSF000197 Bifunct_PutA, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit
SSF53720 SSF53720, 1 hit
SSF81935 SSF81935, 1 hit
TIGRFAMsiTIGR01238 D1pyr5carbox3, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

A1U2B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQQSVAPE LNDIRQAIRA NYLADEHEVI HRLIAEAQLS DETRKAISAR
60 70 80 90 100
AAELVRDVRN SARPTIMEKF LAEYGLTTKE GVALMCLAEA LLRVPDNLTI
110 120 130 140 150
QDLIEDKITS GNWGAHVGKA KSGMINSATL ALLMTSNLLK DSERQSVGDT
160 170 180 190 200
LRKLVKRLGE PVVRTVAGQA MKEMGRQFVL GRTIEEAQDR GKSQEERGYT
210 220 230 240 250
YSYDMLGEAA RTDADAQRYY QAYSDAIDSI SKRCKGDVRT NPGISVKLSA
260 270 280 290 300
LLARYEYGHK ERVMNELMPR ALKLARKAAA ANMGFNIDAE EQDRLDLSLD
310 320 330 340 350
VIEAILSDPE LKDWQGFGVV VQAFGKRASQ TLDWLYALSE KLDRRIMVRL
360 370 380 390 400
VKGAYWDAEI KRAQVMGLSD FPVFTRKACS DVAYLAGARK LLGMTDRIYP
410 420 430 440 450
QFATHNAHSV SAVLELAKDL SRDKFEFQRL HGMGESLHDQ VLEDSGVPCR
460 470 480 490 500
IYAPVGAHKD LLAYLVRRLL ENGANSSFVN QIVDTSITPE EIAKDPIDVV
510 520 530 540 550
VGLGHNLSSK AIVHPSKIFG EQRRNSKGWD ITDPVTVAEI DEGRNRYKSH
560 570 580 590 600
QWKGGPILAV DSVSDEVVEV RNPANPDDLV GHITYTSEAD ISSALGAAQE
610 620 630 640 650
GFKQWSAVPA EERAAMIRRV GDLYEENVHE LFALTTREAG KSLLDAVAEI
660 670 680 690 700
REAVDFAMFY ANEGIRYKND GEARGVMCCI SPWNFPLAIF TGQILANLAA
710 720 730 740 750
GNAVVAKPAE QTSLLAFRAV ELMHQAGIPR AAIQLLPGTG ATVGSGLTSD
760 770 780 790 800
ARVTGVCFTG STATAQRINK AMTEHMEPDA PLVAETGGLN AMIVDSTALP
810 820 830 840 850
EQVVRDVLAS SFQSAGQRCS ALRMLYVQKD IADNLLEMLY GAMEELGIGD
860 870 880 890 900
PWQLSTDVGP VIDENARKKI TDHCQKFEQQ GKLLKKLNVP EKGLFVSPAV
910 920 930 940 950
LQVSGIEELE EEIFGPVLHV ATFEAKDIDK VIDAVNAKGY GLTFGIHSRV
960 970 980 990 1000
DRRIEHIASR IKVGNTYVNR NQIGAIVGSQ PFGGEGLSGT GPKAGGPQYV
1010 1020 1030 1040 1050
RRFLRGEVVE KPAQSSDKVL SADKAQKLID KLAKVEVPEA EGRQALLVPF
1060 1070 1080 1090 1100
FGKVPAPLDE GYEDMPGPTG EQNHLSCHGR GLVLCLGPDA ESAVEQAGTA
1110 1120 1130 1140 1150
LSQGNKVVVI APGAEKALAD AIKAGLPVVA SDGMLDPDAL SHLTGFEAVV
1160 1170 1180 1190 1200
SVAEKPLLKQ YRMALSKRDG ALLPVITEHK LDQRYVIERH LCIDTTAAGG

NASLIASAE
Length:1,209
Mass (Da):131,510
Last modified:February 6, 2007 - v1
Checksum:i03C0386A35B68B11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000514 Genomic DNA Translation: ABM19130.1
RefSeqiWP_011785523.1, NC_008740.1

Genome annotation databases

EnsemblBacteriaiABM19130; ABM19130; Maqu_2049
KEGGimaq:Maqu_2049

Similar proteinsi

Entry informationi

Entry nameiA1U2B1_MARHV
AccessioniPrimary (citable) accession number: A1U2B1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported