Reviewed, UniProtKB/Swiss-Prot A1U1Y5 (STHA_MARAV)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Ordered Locus Names:	Maqu_1923

Organism

Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) [Complete proteome] [HAMAP]

Taxonomic identifier

351348 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Alteromonadaceae › Marinobacter

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247		PRO_1000012558
Regions
	Nucleotide binding	35 – 44	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1U1Y5-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 246C96601E4796B6	FASTA	463	51,452
	10 20 30 40 50 60 MAEHHYDVVV IGAGPSGEGA AMNAAKHNRR VAIIEDKPTV GGNCTHWGTI PSKALRHSVK 70 80 90 100 110 120 QIITFNTNQM FRDIGEPRWF SFPRVLQNAQ KVIGKQVKLR TQFYSRNRVD LINGRAAFVD 130 140 150 160 170 180 KHRLEIRGNK SVETIHFKQA IIATGSRPYL PPDVDFRHHR IYNSDSILNL SHTPRTLIIY 190 200 210 220 230 240 GAGVIGSEYA SIFAGLGVKV DLINPGSRLL SFLDDEISDA LSYHLRNNGV LVRHNEQYES 250 260 270 280 290 300 VKGDDHGVVL SLQSGKKIRA DAFLWCNGRS GNTENLGLEN VGLTPNSRGQ LAVDEHYRTE 310 320 330 340 350 360 VEHIYAAGDV IGWPSLASAA YDQGRAASSD ITQDEYFRFV DDVPTGIYTI PEISSVGKTE 370 380 390 400 410 420 RELTEAKVPY DVGQAFFKDL ARAQITGEAV GMLKILFHRE TREILGIHCF GDQAAEIVHI 430 440 450 460 GQAIMNQEGE ANSLNYFINT TFNYPTMAEA YRVAALNGLN RIF

References

[1]

"Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000514 Genomic DNA. Translation: ABM19004.1.
RefSeq	YP_959191.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4654234.
GenomeReviews	Gene locus Maqu_1923 in contig CP000514_GR.
KEGG	maq:Maqu_1923.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A1U1Y5. GEGNTIE.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00945. HGRDTASE.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

STHA_MARAV

Accession

Primary (citable) accession number: A1U1Y5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)