Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei252ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Maqu_1891
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000000998 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000019211 – 493Glutamate--tRNA ligaseAdd BLAST493

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi351348.Maqu_1891

Structurei

3D structure databases

ProteinModelPortaliA1U1V3
SMRiA1U1V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi249 – 253"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1U1V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRTRIAPS PTGDPHVGTA YVALFNLCFA RQHGGQFILR IEDTDQARST
60 70 80 90 100
AESEQDILTA LRWLGLNWDE GPDVGGPHGP YRQSERKHMY GQYAEDLVTA
110 120 130 140 150
GHAFYCFRTP EELDAIREER KAQGLNPGIK GDLELPEEEV KRRLDAGDPY
160 170 180 190 200
VIRMKVPDEG VCEIQDMLRG TIEIDWAQVD CQILLKSDGM PTYHLANVVD
210 220 230 240 250
DHLMGITHVL RGEEWINSAP KHKLLYQYFG WDMPELCHLP LLRNPDKSKL
260 270 280 290 300
SKRKNPTSIN FYERMGFLPE AVTNYLGRMG WSMPDEREKF TLDEMIENFD
310 320 330 340 350
IQRVSLGGPV FDVEKLRWLN GQWIREELSD EQFMARMQQW WFNQDDLKAL
360 370 380 390 400
VPHIKGRAEV FSDVAPMAQF MFSGMLNLKP EDFAHNKLDE SQVKRVLQFA
410 420 430 440 450
LWKLEAQRHW SKNTIFADIK ALAKAMDLKM GDFMFSIFVA IAGTPNSWSV
460 470 480 490
MDSMALLGPD MTRSRLRHAL EVMGGFSKKE TKKVEKEYAA LGV
Length:493
Mass (Da):56,592
Last modified:February 6, 2007 - v1
Checksum:i837B332158625415
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000514 Genomic DNA Translation: ABM18972.1
RefSeqiWP_011785365.1, NC_008740.1

Genome annotation databases

EnsemblBacteriaiABM18972; ABM18972; Maqu_1891
KEGGimaq:Maqu_1891

Similar proteinsi

Entry informationi

Entry nameiSYE_MARHV
AccessioniPrimary (citable) accession number: A1U1V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health