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Protein

Malate synthase G

Gene

glcB

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glyoxylate cycle

This protein is involved in step 2 of the subpathway that synthesizes (S)-malate from isocitrate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Malate synthase G (glcB)
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118Acetyl-CoA; via carbonyl oxygenUniRule annotation1
Binding sitei276Acetyl-CoAUniRule annotation1
Binding sitei313Acetyl-CoAUniRule annotation1
Active sitei340Proton acceptorUniRule annotation1
Binding sitei340GlyoxylateUniRule annotation1
Metal bindingi432MagnesiumUniRule annotation1
Binding sitei432GlyoxylateUniRule annotation1
Metal bindingi460MagnesiumUniRule annotation1
Binding sitei541Acetyl-CoA; via carbonyl oxygenUniRule annotation1
Active sitei632Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:Maqu_1843
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000000998 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001308901 – 726Malate synthase GAdd BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei618Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Proteomic databases

PRIDEiA1U1Q6

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi351348.Maqu_1843

Structurei

3D structure databases

ProteinModelPortaliA1U1Q6
SMRiA1U1Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 126Acetyl-CoA bindingUniRule annotation2
Regioni457 – 460Glyoxylate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP3 Bacteria
COG2225 LUCA
HOGENOMiHOG000220740
KOiK01638
OMAiTEPVLHA
OrthoDBiPOG091H05P0

Family and domain databases

CDDicd00728 malate_synt_G, 1 hit
Gene3Di2.170.170.11, 1 hit
HAMAPiMF_00641 Malate_synth_G, 1 hit
InterProiView protein in InterPro
IPR011076 Malate_synth-like_sf
IPR023310 Malate_synth_G_beta_sub_dom
IPR001465 Malate_synthase
IPR006253 Malate_synthG
PANTHERiPTHR42739 PTHR42739, 1 hit
PfamiView protein in Pfam
PF01274 Malate_synthase, 1 hit
SUPFAMiSSF51645 SSF51645, 1 hit
TIGRFAMsiTIGR01345 malate_syn_G, 1 hit

Sequencei

Sequence statusi: Complete.

A1U1Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERVQVGGI QIAKNLYDFV NNEAIPGTGI EADKFWAEFD KIVNELAPRN
60 70 80 90 100
RELLLKRDEI QEKMDTWNRE HKGQKLDMAE YKAFLKDIGY LVDEPADFKI
110 120 130 140 150
STSNVDPEIA TMAGPQLVVP VMNARFALNA ANARWGSLYD ALYGTDAISE
160 170 180 190 200
ENGAEKGRGY NPVRGAKVIE WARNLLDGSA PLASGSHKDA AKYYIDGGKL
210 220 230 240 250
AVKLQNGDVT GLKDESGFVG YTGAADAPTG VLLVKNGMHF EIQIDASHPI
260 270 280 290 300
GKDDGAHVKD VLMESALTTI MDCEDSVAAV DADDKVVAYK NWLGLMKGDL
310 320 330 340 350
EESFEKGGQM MTRRMNGDRT YTGADGSELT LKGRSLLFVR NVGHLMTNPA
360 370 380 390 400
ILLKDGSEIP EGLMDGLVTS LIAIHDLKGD GKFQNSTKGS VYIVKPKQHG
410 420 430 440 450
PEEVAFTNEF FGRVEDALGL PRFTLKVGIM DEERRTTVNL KACIHAAKER
460 470 480 490 500
TVFINTGFLD RTGDEIHTSM ELGPFIRKGP MKQAAWINAY EQWNVDIGLE
510 520 530 540 550
AGLSGVAQIG KGMWAMPDLM AGMLEAKIGH PKAGANTAWV PSPTAATLHA
560 570 580 590 600
THYHQVNVFD VQKELANRQR ASLDDILTVP VMEDPSSLSA EDIQQELDNN
610 620 630 640 650
AQGILGYVVR WIDQGVGCSK VPDINDVGLM EDRATLRISS QLLTNWLYHG
660 670 680 690 700
ICSEEQIMET MKRMAAVVDK QNAGDAAYRN MAPNFDDSIA FQAAVDLVLK
710 720
GREQPAGYTE PLLHAYRQKA KAKYGQ
Length:726
Mass (Da):79,629
Last modified:February 6, 2007 - v1
Checksum:iC283C1C0799B0F19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000514 Genomic DNA Translation: ABM18925.1
RefSeqiWP_011785321.1, NC_008740.1

Genome annotation databases

EnsemblBacteriaiABM18925; ABM18925; Maqu_1843
KEGGimaq:Maqu_1843

Similar proteinsi

Entry informationi

Entry nameiMASZ_MARHV
AccessioniPrimary (citable) accession number: A1U1Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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