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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Acyl-thioester intermediateUniRule annotation1
Active sitei347Proton acceptorUniRule annotation1
Active sitei377Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:Maqu_1145
OrganismiMarinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Taxonomic identifieri351348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
Proteomesi
  • UP000000998 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002928921 – 3913-ketoacyl-CoA thiolaseAdd BLAST391

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Protein-protein interaction databases

STRINGi351348.Maqu_1145.

Structurei

3D structure databases

ProteinModelPortaliA1TZR8.
SMRiA1TZR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012239.
KOiK00632.
OMAiCGGTESM.
OrthoDBiPOG091H0I7B.

Family and domain databases

CDDicd00751. thiolase. 1 hit.
Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01620. FadA. 1 hit.
InterProiView protein in InterPro
IPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. fadA. 1 hit.
PROSITEiView protein in PROSITE
PS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A1TZR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNPRDVVV VDCVRTPMGR AKNGCFRNVR AETLSAALIE ALFERNPKLD
60 70 80 90 100
PKEVEDVIWG CVNQTKEQGF NVARQISLLT RIPHESAAQT VNRLCGSAMS
110 120 130 140 150
AIHTAAQAIQ TGNGDVFLVG GVEHMGHVPM TEGFDHNPAA SKYSAKASNM
160 170 180 190 200
MGLTAEMLAK MHGITREQQD EFGARSHRLA HEATQEGRFK NEIVPIEGHD
210 220 230 240 250
ENGFVKLIEE DETIRPETTA ESLGQLRPAF DPKNGTVTAG TSSQLTDGAS
260 270 280 290 300
AMVLMSAERA EALGLTPIAK IRSMAVAGCD PAIMGYGPVP ATKKALKRAG
310 320 330 340 350
LKVEDIDFWE LNEAFAGQSL PVLKDLKLLG VMEEKVNLNG GAIALGHPLG
360 370 380 390
CSGARISTTL LNIMQAKGGK LGVSTMCIGL GQGIATVWER I
Length:391
Mass (Da):41,807
Last modified:February 6, 2007 - v1
Checksum:i4F41504DAF44E782
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000514 Genomic DNA. Translation: ABM18237.1.
RefSeqiWP_011784654.1. NC_008740.1.

Genome annotation databases

EnsemblBacteriaiABM18237; ABM18237; Maqu_1145.
GeneIDi31821539.
KEGGimaq:Maqu_1145.

Similar proteinsi

Entry informationi

Entry nameiFADA_MARHV
AccessioniPrimary (citable) accession number: A1TZR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 6, 2007
Last modified: September 27, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families