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A1TY08

- TRMB_MARAV

UniProt

A1TY08 - TRMB_MARAV

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei68 – 681S-adenosyl-L-methionineUniRule annotation
    Binding sitei93 – 931S-adenosyl-L-methionineUniRule annotation
    Binding sitei120 – 1201S-adenosyl-L-methionineUniRule annotation
    Active sitei143 – 1431By similarity
    Binding sitei143 – 1431S-adenosyl-L-methionineUniRule annotation
    Binding sitei147 – 1471SubstrateUniRule annotation
    Binding sitei179 – 1791SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciMHYD351348:GHYZ-529-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:Maqu_0526
    OrganismiMarinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845))
    Taxonomic identifieri351348 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter
    ProteomesiUP000000998: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238tRNA (guanine-N(7)-)-methyltransferasePRO_0000288176Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351348.Maqu_0526.

    Structurei

    3D structure databases

    ProteinModelPortaliA1TY08.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni216 – 2194Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiMSTENEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1TY08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDQNETQDT NPVTTRRGVR SFVLRQGRMT EGQKKAFDRN WAKYGLSRDN    50
    GMIDPREVFG RDNMLNLEIG FGMGKSLADM AEAAPEQDFI GVEVHLPGVG 100
    ALLKEVESRG LENVRVYSID ANDVIDLCLP DACLDRVMVF FPDPWHKKKH 150
    HKRRLIQPEF VQRIRHKLRV GGILHLATDW ENYAEHMLEV MSASEGFANT 200
    QEQGGYSPKP DDRPITKFEK RGESLGHGVW DLLFYRTN 238
    Length:238
    Mass (Da):27,228
    Last modified:February 6, 2007 - v1
    Checksum:iCEE8D05719AF80CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000514 Genomic DNA. Translation: ABM17627.1.
    RefSeqiYP_957814.1. NC_008740.1.

    Genome annotation databases

    EnsemblBacteriaiABM17627; ABM17627; Maqu_0526.
    GeneIDi4656224.
    KEGGimaq:Maqu_0526.
    PATRICi22456250. VBIMarAqu65105_0922.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000514 Genomic DNA. Translation: ABM17627.1 .
    RefSeqi YP_957814.1. NC_008740.1.

    3D structure databases

    ProteinModelPortali A1TY08.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351348.Maqu_0526.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM17627 ; ABM17627 ; Maqu_0526 .
    GeneIDi 4656224.
    KEGGi maq:Maqu_0526.
    PATRICi 22456250. VBIMarAqu65105_0922.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi MSTENEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci MHYD351348:GHYZ-529-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.
      , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700491 / DSM 11845 / VT8.

    Entry informationi

    Entry nameiTRMB_MARAV
    AccessioniPrimary (citable) accession number: A1TY08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3