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A1TY02 (SPEA_MARAV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Maqu_0520
OrganismMarinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) [Complete proteome] [HAMAP]
Taxonomic identifier351348 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeMarinobacter

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000024257

Regions

Region286 – 29611Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1TY02 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 0D871076F7FD711C

FASTA63770,502
        10         20         30         40         50         60 
MAETAASPAH KVYNIAHWSD GYISVNGQGE VEICPDRGRS DARINLPALT RSLAEAGVPL 

        70         80         90        100        110        120 
PVLIRFTDIL HDRVNKLCNA FNKVTQEQGY RGRYTAVYPI KVNQQRRVVE ELLSAEPAAS 

       130        140        150        160        170        180 
ANQVGLEAGS KPELMAVLAL AKQAGSVIVC NGYKDREYIR LALIGQKLGH RVFIVVEKQS 

       190        200        210        220        230        240 
ELPLILEEAK KLGISPLIGV RARLATIGKG NWQNTGGEKS KFGLSASQVL DVVDTLKQAG 

       250        260        270        280        290        300 
ALGTLQLLHF HLGSQIANIR DIQTGLRECA RFYTELHAMG APIGTVDIGG GLGVDYEGTR 

       310        320        330        340        350        360 
SRSSCSMNYS VFEYAYNVVH VLQSECDRQG IPHPDLISES GRALTAHHSV LVTNVIDREY 

       370        380        390        400        410        420 
PDNREPTEPA AEAPAPLQDL WRDLESLQDE DSPRSLAEIY HDILHAMADV HAQFAHGLLS 

       430        440        450        460        470        480 
LQERAQAETL YVRCCRMLRA ELDSANRAHR EIIDELNEKL AEKLFVNFSL FQSLPDVWGI 

       490        500        510        520        530        540 
DQIFPVMPIN GLNRSLNRRA VIQDITCDSD GRIDQYVDGQ GIETTLPLPE HDPESPLLMG 

       550        560        570        580        590        600 
FFMTGAYQEI LGDMHNLFGD THSVDVKLDQ QGQYQVGEPI TGDTVAKVLR YVNFEPANLL 

       610        620        630 
EAYRQKFRHS GLSEELQQTL LAELSSGLEG YTYLEEG 

« Hide

References

[1]"Complete sequence of chromosome 1 of Marinobacter aquaeolei VT8."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Edwards K., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700491 / DSM 11845 / VT8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000514 Genomic DNA. Translation: ABM17621.1.
RefSeqYP_957808.1. NC_008740.1.

3D structure databases

ProteinModelPortalA1TY02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351348.Maqu_0520.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM17621; ABM17621; Maqu_0520.
GeneID4656218.
KEGGmaq:Maqu_0520.
PATRIC22456236. VBIMarAqu65105_0915.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycMHYD351348:GHYZ-523-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_MARAV
AccessionPrimary (citable) accession number: A1TY02
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways