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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Aave_4696
OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Taxonomic identifieri397945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000002596 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000664531 – 274Orotidine 5'-phosphate decarboxylaseAdd BLAST274

Interactioni

Protein-protein interaction databases

STRINGi397945.Aave_4696.

Structurei

3D structure databases

ProteinModelPortaliA1TW93.
SMRiA1TW93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105SKN. Bacteria.
COG0284. LUCA.
HOGENOMiHOG000245747.
KOiK01591.
OMAiQSAFFER.
OrthoDBiPOG091H09O1.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00215. OMPdecase. 1 hit.
SMARTiView protein in SMART
SM00934. OMPdecase. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiView protein in PROSITE
PS00156. OMPDECASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1TW93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFIDMLRGA TARNDSLLCV GLDPEPSRFP AGLRGDAGRI YDFCAAIVDA
60 70 80 90 100
TADLACAFKP QIAYFAAHRA EEQLERLMRH MRATAPHVPV ILDAKRGDIG
110 120 130 140 150
STAQQYAIEA FERYGADAVT LSPFMGFDSI EPYLAYHGKG AFLLCRTSNP
160 170 180 190 200
GGDDLQSQRL ASVDGQPLLF EHIARQAQGP WNRNGQLGLV VGATYPAEIE
210 220 230 240 250
RVRALAPTLP LLIPGVGAQG GDAAATVRAG LRPDGPVVVN SSRAILYASA
260 270
DEGFAAAARQ AAQATRDALN AARG
Length:274
Mass (Da):29,077
Last modified:February 6, 2007 - v1
Checksum:iAD092E5391E7621B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000512 Genomic DNA. Translation: ABM35231.1.
RefSeqiWP_011797697.1. NC_008752.1.

Genome annotation databases

EnsemblBacteriaiABM35231; ABM35231; Aave_4696.
KEGGiaav:Aave_4696.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPYRF_ACIAC
AccessioniPrimary (citable) accession number: A1TW93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families