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Protein

Adenylosuccinate lyase

Gene

Aave_4669

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (Aave_3210), Adenylosuccinate lyase (Aave_4669)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Aave_3210), Adenylosuccinate lyase (Aave_4669)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciACIT397945:G1G7T-4763-MONOMER
UniPathwayiUPA00074; UER00132
UPA00075; UER00336

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Ordered Locus Names:Aave_4669Imported
OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)Imported
Taxonomic identifieri397945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000002596 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi397945.Aave_4669

Structurei

3D structure databases

ProteinModelPortaliA1TW66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 316Lyase_1InterPro annotationAdd BLAST303
Domaini335 – 449ASL_CInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTF Bacteria
COG0015 LUCA
HOGENOMiHOG000252916
KOiK01756
OMAiTQVNPCD
OrthoDBiPOG091H01RB

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR004769 Pur_lyase
IPR013539 PurB_C
PfamiView protein in Pfam
PF08328 ASL_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00928 purB, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A1TW66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSTINALS PLDGRYAAKL SALRPIMSEH GYMHRRVQVE VAWFIALSDA
60 70 80 90 100
GFEQFKPLTT GARAYLLSLV KNFSEADSQA IKDIEKTTNH DVKAVEYWIK
110 120 130 140 150
SKFEARPELE RAAEFVHFAC TSEDINNTSH ALQLRSGRDQ VILPGLDRIV
160 170 180 190 200
LKLREMAHAY AEVPMLSRTH GQTASPTTVG KELANVVVRL QAACDRIAGV
210 220 230 240 250
KMLGKMNGAV GNYNAHLSAW PDFDWEAFSR KVVETPEPLG LGLTFQPYSI
260 270 280 290 300
QIEPHDYMAE LFDAIARANT ILVDLSRDIW GYVSLGYFKQ RLKAGEIGSS
310 320 330 340 350
TMPHKVNPID FENAEGNLGL ANALLRHLSE KLPVSRWQRD LTDSTVLRNI
360 370 380 390 400
GVAMGYAALA YTSLMTGLNK LELNEEALAA DLDASWEVLA EPIQTVMRRY
410 420 430 440 450
GVQGAYEKLK EVTRGKTVTA EALHALIAGL EIPQADKDRL LAMTPGSYVG

KAAELARRV
Length:459
Mass (Da):50,782
Last modified:February 6, 2007 - v1
Checksum:i07263A2D051CE24C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000512 Genomic DNA Translation: ABM35204.1
RefSeqiWP_011797670.1, NC_008752.1

Genome annotation databases

EnsemblBacteriaiABM35204; ABM35204; Aave_4669
KEGGiaav:Aave_4669

Similar proteinsi

Entry informationi

Entry nameiA1TW66_ACIAC
AccessioniPrimary (citable) accession number: A1TW66
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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