Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1TVU7 (SYL_ACIAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Aave_4548
OrganismAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli) [Complete proteome] [HAMAP]
Taxonomic identifier397945 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax

Protein attributes

Sequence length897 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 897897Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009284

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif645 – 6495"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6481ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1TVU7 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 9B4C0A3011D76274

FASTA89799,830
        10         20         30         40         50         60 
MQDKYTPAEV ERAAHSHWTA RDAYRVTEDA GKKKFYACSM LPYPSGKLHM GHVRNYTIND 

        70         80         90        100        110        120 
MLTRYLRMNG HNVLMPMGWD AFGLPAENAA LKNGVPPAQW TYDNIAYMKK QMQAMGLAID 

       130        140        150        160        170        180 
WSREVATCDP DYYKWNQWLF LKMLEKGIAY RKTQVVNWDP VDQTVLANEQ VIDGRGWRTG 

       190        200        210        220        230        240 
ALVEKREIPG YYLKITDYAQ ELLDHVQVGN PNATLTGWPD KVRLMQENWI GKSEGVRFAF 

       250        260        270        280        290        300 
THDIRGEDGQ PIGDGRMYVF TTRADTIMGV TFCAVAPEHP LAAHAARSNP DVAAFIQECK 

       310        320        330        340        350        360 
TGGTTEAELA TQEKKGVRTG LTVTHPLTDE PIEVWVGNYV LMGYGDGAVM GVPAHDERDF 

       370        380        390        400        410        420 
AFALKYGIEI KQVVLVDGET FDYHRWQDWY GDKQNGVTIN SDNFSGLSYQ EAVSAVAHAL 

       430        440        450        460        470        480 
QEKGLGEKKT TWRLRDWGVS RQRYWGTPIP IIHCDEHGAV PVPEKDLPVV LPQDCIPDGS 

       490        500        510        520        530        540 
GNPLHKHEGF HAGVKCPVCG KAARRETDTM DTFVDSSWYF MRYCDPKNAD AMVAGGADYW 

       550        560        570        580        590        600 
MPMDQYIGGI EHAILHLLYA RFWTKVMRDL GLVKVDEPFT KLLTQGMVLN HIYSRRTDKG 

       610        620        630        640        650        660 
GKEYFWPHDV EHIQDEAGKI TGARLKNAVG DLPAGTPIDY EGVGTMSKSK NNGVDPQELI 

       670        680        690        700        710        720 
EKYGADTARL YTMFTAPPEA TLEWNDAAVE GSYRFLRRVW NFGVKLAGID AAATEAAIQG 

       730        740        750        760        770        780 
AQSLQDVQFG KEAKALRLEI HTVLKQVDYD YQRMQYNTVV SGAMKMLNAL EDFKSADAPG 

       790        800        810        820        830        840 
GLVALIEGFG ILLRVLYPAT PHIAHGLWSG LGYAGSLGDL LDAPWPQVDA GALMQDEIEL 

       850        860        870        880        890 
VLQINGKLRG AIRVPSGADK AEIERIALAS EDFHKHAAGA APKKVVVVPG RLVNVVV 

« Hide

References

[1]"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AAC00-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000512 Genomic DNA. Translation: ABM35085.1.
RefSeqYP_972859.1. NC_008752.1.

3D structure databases

ProteinModelPortalA1TVU7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING397945.Aave_4548.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM35085; ABM35085; Aave_4548.
GeneID4668255.
KEGGaav:Aave_4548.
PATRIC20684357. VBIAciCit38535_4628.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycACIT397945:GI5W-4610-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_ACIAC
AccessionPrimary (citable) accession number: A1TVU7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries