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A1TVU7

- SYL_ACIAC

UniProt

A1TVU7 - SYL_ACIAC

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei648 – 6481ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACIT397945:GI5W-4610-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Aave_4548
OrganismiAcidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli)
Taxonomic identifieri397945 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000002596: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 897897Leucine--tRNA ligasePRO_1000009284Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi397945.Aave_4548.

Structurei

3D structure databases

ProteinModelPortaliA1TVU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi645 – 6495"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1TVU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDKYTPAEV ERAAHSHWTA RDAYRVTEDA GKKKFYACSM LPYPSGKLHM
60 70 80 90 100
GHVRNYTIND MLTRYLRMNG HNVLMPMGWD AFGLPAENAA LKNGVPPAQW
110 120 130 140 150
TYDNIAYMKK QMQAMGLAID WSREVATCDP DYYKWNQWLF LKMLEKGIAY
160 170 180 190 200
RKTQVVNWDP VDQTVLANEQ VIDGRGWRTG ALVEKREIPG YYLKITDYAQ
210 220 230 240 250
ELLDHVQVGN PNATLTGWPD KVRLMQENWI GKSEGVRFAF THDIRGEDGQ
260 270 280 290 300
PIGDGRMYVF TTRADTIMGV TFCAVAPEHP LAAHAARSNP DVAAFIQECK
310 320 330 340 350
TGGTTEAELA TQEKKGVRTG LTVTHPLTDE PIEVWVGNYV LMGYGDGAVM
360 370 380 390 400
GVPAHDERDF AFALKYGIEI KQVVLVDGET FDYHRWQDWY GDKQNGVTIN
410 420 430 440 450
SDNFSGLSYQ EAVSAVAHAL QEKGLGEKKT TWRLRDWGVS RQRYWGTPIP
460 470 480 490 500
IIHCDEHGAV PVPEKDLPVV LPQDCIPDGS GNPLHKHEGF HAGVKCPVCG
510 520 530 540 550
KAARRETDTM DTFVDSSWYF MRYCDPKNAD AMVAGGADYW MPMDQYIGGI
560 570 580 590 600
EHAILHLLYA RFWTKVMRDL GLVKVDEPFT KLLTQGMVLN HIYSRRTDKG
610 620 630 640 650
GKEYFWPHDV EHIQDEAGKI TGARLKNAVG DLPAGTPIDY EGVGTMSKSK
660 670 680 690 700
NNGVDPQELI EKYGADTARL YTMFTAPPEA TLEWNDAAVE GSYRFLRRVW
710 720 730 740 750
NFGVKLAGID AAATEAAIQG AQSLQDVQFG KEAKALRLEI HTVLKQVDYD
760 770 780 790 800
YQRMQYNTVV SGAMKMLNAL EDFKSADAPG GLVALIEGFG ILLRVLYPAT
810 820 830 840 850
PHIAHGLWSG LGYAGSLGDL LDAPWPQVDA GALMQDEIEL VLQINGKLRG
860 870 880 890
AIRVPSGADK AEIERIALAS EDFHKHAAGA APKKVVVVPG RLVNVVV
Length:897
Mass (Da):99,830
Last modified:February 6, 2007 - v1
Checksum:i9B4C0A3011D76274
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000512 Genomic DNA. Translation: ABM35085.1.
RefSeqiYP_972859.1. NC_008752.1.

Genome annotation databases

EnsemblBacteriaiABM35085; ABM35085; Aave_4548.
GeneIDi4668255.
KEGGiaav:Aave_4548.
PATRICi20684357. VBIAciCit38535_4628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000512 Genomic DNA. Translation: ABM35085.1 .
RefSeqi YP_972859.1. NC_008752.1.

3D structure databases

ProteinModelPortali A1TVU7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 397945.Aave_4548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM35085 ; ABM35085 ; Aave_4548 .
GeneIDi 4668255.
KEGGi aav:Aave_4548.
PATRICi 20684357. VBIAciCit38535_4628.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ACIT397945:GI5W-4610-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.
    , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AAC00-1.

Entry informationi

Entry nameiSYL_ACIAC
AccessioniPrimary (citable) accession number: A1TVU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3