Reviewed, UniProtKB/Swiss-Prot A1TVM0 (DCUP_ACIAC)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Aave_4469

Organism

Acidovorax avenae subsp. citrulli (strain AAC00-1) [Complete proteome] [HAMAP]

Taxonomic identifier

397945 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000325619
Regions
	Region	29 – 33	5	Substrate binding By similarity
Sites
	Binding site	79	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	342	1	Substrate By similarity
	Site	79	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1TVM0-1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 4B876CB39FF1667A	FASTA	376	40,416
	10 20 30 40 50 60 MSFAPLQNDT FLRACRRQAT DYTPLWLMRQ AGRYLPEYKA TRARAGSFMG LATNVDYATE 70 80 90 100 110 120 VTLQPLERFP LDAAILFSDI LTVPDAMGLG LSFAEGEGPR FARVVRDEAA VAELAVPDME 130 140 150 160 170 180 KLRYVFDAVT SIRRALDGRV PLIGFSGSPW TLACYMVEGS GSDDYRLVKT LMYSRPDLMH 190 200 210 220 230 240 RILAINADAV AAYLNAQIDA GAQAVMVFDS WGGVLADGAF QEFSLAYTTR VLAQLKRTGV 250 260 270 280 290 300 DGTDVPRIVF TKGGALWLED MKGLDCEVLG LDWTANLARA RALVGGAVGG PGKALQGNID 310 320 330 340 350 360 PNVLFAPPEA IAAQARAVLD RFGAPHTDRG TTGPTHIFNL GHGISQHTPP EHVAALVEAV 370 HGHSRAMRAA AGTGRA

References

[1]

"Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000512 Genomic DNA. Translation: ABM35008.1. Different initiation.
RefSeq	YP_972782.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1TVM0.
Genome annotation databases
GeneID	4667198.
GenomeReviews	Gene locus Aave_4469 in contig CP000512_GR.
KEGG	aav:Aave_4469.
NMPDR	fig|397945.5.peg.3847.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_ACIAC

Accession

Primary (citable) accession number: A1TVM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	September 1, 2009
This is version 22 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)